目的 研究降糖宁胶囊联合门冬胰岛素注射液治疗妊娠糖尿病的临床疗效。方法 选取2018年8月-2019年8月在陕西省人民医院和西北妇女儿童医院治疗的120例妊娠糖尿病患者为研究对象，所有患者随机分为对照组和治疗组，每组各60例。对照组患者给予门冬胰岛素注射液，推荐剂量为0.5~1.0 U/kg，2/3用量在用餐时给药，剩余的1/3用量为基础胰岛素；治疗组在对照组的基础上口服降糖宁胶囊，4粒/次，3次/d。两组患者持续治疗4周。观察两组的临床疗效，比较两组的血糖水平和C-反应蛋白（CRP）、血清镁（Mg²⁺）、脂联素水平、低血糖发生率、每日胰岛素用量、血糖达标时间。结果 治疗后，对照组和治疗组的总有效率分别为83.33%、95.00%，两组比较差异有统计学意义（P<0.05）。治疗后，两组血清糖化血红蛋白（HbA1c）、餐后2 h血糖（2 h PG）和空腹血糖（FBG）水平均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组HbA1c、2 h PG和FPG水平均明显低于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组CRP水平明显降低，Mg²⁺、脂联素水平均明显升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组CRP、Mg²⁺和脂联素水平均明显优于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，治疗组低血糖发生率、每日胰岛素用量、血糖达标时间明显低于对照组，两组比较差异有统计学意义（P<0.05）。结论 降糖宁胶囊联合门冬胰岛素注射液治疗妊娠糖尿病具有较好的治疗效果，可降低血糖水平，调节CRP、Mg²⁺和脂联素水平，降低胰岛素使用量，安全性较高，具有一定的临床推广应用价值。

Objective To study the effect of Jiangtangning Capsules combined with Insulin Aspart Injection in treatment of gestational diabetes mellitus. Methods Patients (120 cases) with gestational diabetes mellitus in Shanxi Provincial People's Hospital and Northwest Women and Children Hospital from August 2018 to August 2019 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were given Insulin Aspart Injection, the recommended dose was 0.5-1.0 U/kg, 2/3 dosage was given at meal time, and the remaining dosage was basic insulin. Patients in the treatment group were po administered with Jiangtangning Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and blood glucose levels, the levels of CRP, Mg²⁺, and adiponectin, the incidence of hypoglycemia, the daily insulin dosage, and the time of blood glucose reaching the standard in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 83.33% and 95.00%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of HbA1c, 2 h PG and FPG in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of CRP in two groups were significantly decreased, but the levels of Mg²⁺ and adiponectin in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the incidence of hypoglycemia, the daily insulin dosage, and the time of blood glucose reaching the standard in the treatment group were significantly lower than those in the control group, and there was difference between two groups (P<0.05). Conclusion Jiangtangning Capsules combined with Insulin Aspart Injection has clinical curative effect in treatment of gestational diabetes mellitus, can reduce the level of blood glucose, regulate the level of CRP, Mg²⁺, and adiponectin, and reduce the use of insulin, which has a certain clinical application value.