目的 探讨甘草酸铋散联合泮托拉唑钠肠溶片治疗十二指肠溃疡的临床疗效。方法 选取2018年2月-2019年2月在天津市西青医院治疗的十二指肠溃疡患者88例，按照治疗方法的差别分为对照组（44例）和治疗组（44例）。对照组口服泮托拉唑钠肠溶片，40 mg/次，1次/d；治疗组在对照组基础上口服甘草酸铋散，1 g/次，3次/d。两组患者经4周治疗。观察两组患者临床疗效，同时比较治疗前后两组患者症候积分、血清白细胞介素-1β（IL-1β）、白细胞介素-18（IL-18）、白细胞介素-23（IL-23）、血管内皮生长因子（VEGF）、高迁移率族蛋白1（HMGB1）、前列腺素E2（PGE2）、肾上腺髓质素（AM）、胃泌素（GAS）、生长抑素（SS）和降钙素基因相关肽水平（CGRP）水平，及GQOL-74量表评分。结果 治疗后，对照组和治疗组临床有效率分别为81.82%和97.73%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者症候积分显著下降（P<0.05），且治疗组患者这些症候积分明显低于对照组（P<0.05）。治疗后，两组患者血清AM、GAS、IL-1β、IL-8、IL-23和HMGB1水平水平均明显下降（P<0.05），而CGRP、SS、VEGF和PGE2水平均明显升高（P<0.05），且治疗组患者这些细胞因子水平明显好于对照组（P<0.05）。治疗后，两组患者GQOL-74量表评分均明显升高（P<0.05），且治疗组患者GQOL-74量表评分明显高于对照组（P<0.05）。结论 甘草酸铋散联合泮托拉唑钠肠溶片治疗十二指肠溃疡可有效改善患者临床症状，降低机体炎症反应，促进溃疡愈合。

Objective To investigate the clinical efficacy of Bismuth Glycyrrhizinate Powder Combined with pantoprazole in treatment of duodenal ulcer. Methods Patients (88 cases) with duodenal ulcer in Tianjin Xiqing Hospital from February 2018 to February 2019 were divided into control (44 cases) and treatment (44 cases) groups based on different treatments. Patients in the control group were po administered with Pantoprazole Sodium Enteric-coated Tablets, 40 mg/time, once daily. Patients in the treatment group were po administered with Bismuth Glycyrrhizinate Powder on the basis of the control group, 1 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the symptom scores, the serum levels of AM, GAS, IL-1β, IL-8, IL-23, HMGB1, CGRP, SS, VEGF and PGE2, and the GQOL-74 scale scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 81.82% and 97.73% respectively, and there were differences between two groups (P<0.05). After treatment, the symptom scores in two groups were significantly decreased (P<0.05), which in the treatment group were significantly lower than that in the control group (P<0.05). After treatment, the serum levels of AM, GAS, IL-1β, IL-8, IL-23 and HMGB1 in two groups were significantly decreased (P<0.05), but the CGRP, SS, VEGF and PGE2 levels were significantly increased (P<0.05), and these cytokine levels in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the GQOL-74 scale scores in two groups were significantly increased (P<0.05), and which in the treatment group were significantly higher than that in the control group (P<0.05). Conclusion Bismuth Glycyrrhizinate Powder Combined with pantoprazole in treatment of duodenal ulcer can effectively improve the clinical symptoms, reduce the inflammatory response, and promote ulcer healing