目的 探讨解郁丸联合盐酸舍曲林片治疗抑郁症的临床疗效。方法 选取2018年2月-2018年12月在沈阳市安宁医院治疗的抑郁症患者70例，根据用药的差别分为对照组（35例）和治疗组（35例）。对照组口服盐酸舍曲林片，50 mg/次，1次/d；治疗组在对照组基础上口服解郁丸，1.8 g/次，3次/d。两组患者均经4周治疗。观察两组患者临床疗效，同时比较治疗前后两组患者PSQI、HAMD、BDI和GQOLI-74评分，白胞介素-2（IL-2）、IL-6、肿瘤坏死因子-α（TNF-α）、IL-1β、同型半胱氨酸（Hcy）、5羟色胺（5-HT）、去甲肾上腺素（NE）和多巴胺（DA）水平。结果 治疗后，对照组和治疗组临床有效率分别为80.00%和97.14%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者PSQI、HAMD、BDI评分均显著降低（P<0.05），而GQOLI-74评分均显著升高（P<0.05），且治疗组患者PSQI、HAMD、BDI和GQOLI-74评分明显好于对照组（P<0.05）。治疗后，两组患者血清IL-2、IL-6、TNF-α、IL-1β、Hcy水平均明显降低（P<0.05），且治疗组患者血清IL-2、IL-6、TNF-α、IL-1β、Hcy水平明显低于对照组（P<0.05）。治疗后，两组患者5-HT、NE、DA水平均明显升高（P<0.05），且治疗组患者5-HT、NE、DA水平明显高于对照组（P<0.05）。结论 解郁丸联合盐酸舍曲林片治疗抑郁症可有效改善患者抑郁状态，促进单胺类神经递质分泌。

Objective To explore the clinical efficacy of Jieyu Pills combined with sertraline in treatment of depression. Methods Patients (70 cases) with depression in Shenyang Anning Hospital from February 2018 to December 2018 were divided into control (35 cases) and treatment (35 cases) groups based on different treatments. Patients in the control group were po administered with Sertraline Hydrochloride Tablets, 50 mg/time, once daily. Patients in the treatment group were po administered with Jieyu Pills on the basis of the control group, 1.8 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the PSQI, HAMD, BDI and GQOLI-74 scores, the IL-2, IL-6, TNF-α, IL-1β, Hcy, 5-HT, NE, and DA levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 80.00%, and 97.14% respectively, and there were differences between two groups (P<0.05). After treatment, the PSQI, HAMD, and BDI scores in two groups were significantly decreased (P<0.05), but GQOLI-74 scores were significantly increased (P<0.05), and these scores in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the serum levels of IL-2, IL-6, TNF-α, IL-1β, Hcy in two groups were significantly decreased (P<0.05), and these serological indexes levels in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the 5-HT, NE, and DA levels in two groups were significantly increased (P<0.05), and these monoamine neurotransmitters levels in the treatment group were significantly higher than those in the control group (P<0.05). Conclusion Jieyu Pills combined with sertraline in treatment of depression can effectively improve depression, promote the secretion of monoamine neurotransmitters.

沈阳市卫计委科研课题计划项目（2018-277-105）