目的 探讨盾叶冠心宁片联合氟伐他汀钠胶囊治疗高脂血症的临床疗效。方法 选取2018年2月-2019年2月在西宁市第三人民医院治疗的高脂血症患者102例，将患者根据药品应用的差别分为治疗组与对照组（每组51例）。对照组睡前口服氟伐他汀钠胶囊，20 mg/次，1次/d，必要时可40 mg/次，1次/d；治疗组除了给予氟伐他汀钠胶囊外还给予盾叶冠心宁片，0.32 g/次，3次/d，口服。两组均经4周治疗。观察两组患者临床疗效，同时比较治疗前后两组患者血脂水平、血清超敏C反应蛋白（hs-CRP）、摄食抑制因子-1（NSF-1）、P选择素（CD62P）、干扰素-γ（IFN-γ）、白细胞介素-1β（IL-1β）和脂联素（ADP）水平及肥胖指标体质量（W）、肥胖度（A）、体质量指数（BMI）和体脂率（F）。结果 治疗后，在有效率上对照组为80.39%，远低于治疗组（96.08%，P<0.05）。经治疗，两组TC、TG、LDL-C表达均降低，HDL-C表达均增高，但治疗组最明显（P<0.05）。经治疗，两组血清hs-CRP、NSF-1、CD62P、IFN-γ、IL-1β表达均下降，ADP表达均增高，且以治疗组最为显著（P<0.05）。治疗后，两组W、A、BMI、F水平均降低，且以治疗组最为显著（P<0.05）。结论 高脂血症采用盾叶冠心宁片与氟伐他汀钠胶囊共同治疗能够明显改善患者血脂，促进机体细胞因子的改善，有利于肥胖指标的恢复，有着很好应用价值。

Objective To explore the clinical effect of Dunye Guanxinning Tablets combined with fluvastatin in treatment of hyperlipidemia. Methods A total of 102 patients with hyperlipemia who were treated in the Third People's Hospital of Xining from February 2018 to February 2019 were divided into treatment group and control group (51 cases in each group) according to the difference of drug use. The control group was given Fluvastatin Sodium Capsules 20 mg once a day, 40 mg once a day if necessary, and the treatment group was given Fluvastatin Sodium Capsules and Dunye Guanxinning Tablets 0.32 g three times a day. Both groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the levels of serum lipid, serum high sensitive c-reactive protein (hs-CRP), NSF-1, CD62P, IFN-γ, IL-1β and ADP, body mass index (W), obesity degree (A), body mass index (BMI) and body fat rate (F) were compared before and after treatment. Results After treatment, the effective rate of the control group was 80.39%, much lower than that of the treatment group (96.08%, P<0.05). After treatment, the expression of TC, TG, LDL-C decreased, and the level of HDL-C increased in both groups, but the treatment group was the most significant (P<0.05). After treatment, the expression of hs CRP, NSF-1, CD62P, IFN-γ, IL-1β decreased, and the expression of ADP increased in both groups, especially in the treatment group (P<0.05). After treatment, W, A, BMI and F decreased in the two groups, and the treatment group was the most significant (P<0.05). Conclusion The treatment of hyperlipidemia with Dunye Guanxinning Tablets and Fluvastatin Sodium Capsules can obviously improve the blood lipid of patients, and can promote the improvement of cytokines, facilitate the recovery of obesity indexes, and which has a good application value.