目的 探讨新癀片联合盐酸米诺环素软膏治疗牙周炎的临床疗效。方法 选取2017年10月-2018年10月中国人民解放军联勤保障部队第九六〇医院收治的100例牙周炎患者为研究对象，将患者随机分为对照组和治疗组，每组各50例。对照组给予盐酸米诺环素软膏，将软膏注满患部牙周袋内，1次/周；治疗组在对照组治疗的基础上口服新癀片，3片/次，3次/d。两组患者持续治疗4周。观察两组的临床疗效，比较两组的牙周指标、血清炎症因子水平。结果 治疗后，对照组和治疗组的总有效率分别为82.00%、92.00%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者龈沟出血指数（SBI）、牙龈指数（GI）、菌斑指数（PLI）和牙周袋深度（PD）均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；并且治疗组患者牙周指标明显低于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者C反应蛋白（CRP）、肿瘤坏死因子α（TNF-α）、白细胞介素-6（IL-6）水平均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；并且治疗组患者血清炎症因子水平明显低于对照组，两组比较差异有统计学意义（P<0.05）。结论 新癀片联合盐酸米诺环素软膏治疗牙周炎的临床疗效较好，能改善牙周状况，缓解炎症反应，具有一定的临床推广应用价值。

Objective To investigate the efficacy of Xinhuang Tablets combined with Minocycline Hydrochloride Ointment in treatment of periodontitis. Methods Patients (100 cases) with periodontitis in the 960th Hospital of Joint Logistics Support Force of PLA from October 2017 to October 2018 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were given Minocycline Hydrochloride Ointment, filled the periodontal bag with ointment, 100 mg/time, once weekly. Patients in the treatment group were po administered with Xinhuang Tablets on the basis of the control group, 3 tablets/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and periodontal indexes and serum levels of inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.00% and 92.00%, respectively, and there was difference between two groups (P<0.05). After treatment, SBI, GI, PLI, and PD in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the periodontal indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of CRP, TNF-α, and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the serum levels of inflammatory factors in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Xinhuang Tablets combined with Minocycline Hydrochloride Ointment has clinical curative effect in treatment of periodontitis, can improve the periodontal condition, and alleviate the inflammatory reaction, which has a certain clinical application value.