目的 探讨栀子金花丸联合复方庆大霉素膜治疗复发性口腔溃疡的临床疗效。方法 选取2017年6月-2018年6月在北京大学首钢医院治疗的复发性口腔溃疡患者146例，根据住院号分为对照组（73例）和治疗组（73例）。对照组给予复方庆大霉素膜，取略大于溃疡面的药物膜贴于溃疡面上，3~4次/d；治疗组在对照组基础上口服栀子金花丸，9 g/次，1次/d。两组患者均经14 d治疗。观察两组患者临床疗效，同时比较治疗前后两组患者症状评分，血清超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、IL-17水平及SF-36量表评分。结果 治疗后，对照组临床有效率为80.82%，显著低于治疗组的97.26%，两组比较差异有统计学意义（P<0.05）。治疗后，两组溃疡疼痛、烧灼感、溃疡面积、溃疡渗出、溃疡充血、水肿、口干口渴、便干便秘评分均显著下降（P<0.05），且治疗组这些症状评分明显低于对照组（P<0.05）。治疗后，两组hs-CRP、IL-6、TNF-α、IL-17水平均明显降低（P<0.05），且治疗组hs-CRP、IL-6、TNF-α、IL-17水平明显低于对照组（P<0.05）。治疗后，两组SF-36量表评分均明显升高（P<0.05），且治疗组SF-36评分明显高于对照组（P<0.05）。结论 栀子金花丸联合复方庆大霉素膜治疗复发性口腔溃疡能够明显改善其临床症状，降低机体炎症反应，提高患者生活质量。

Objective To explore the clinical effect of Zhizi Jinhua Pills combined with Compound Gentamycin Pellicles in treatment of recurrent oral mucosal ulcer. Methods Patients (146 cases) with recurrent oral mucosal ulcer in Peking University Shougang Hospital from June 2017 to June 2018 were divided into control (73 cases) and treatment (73 cases) groups based on hospitalization number. Patients in the control group were administered with Compound Gentamycin Pellicles, the pellicles slightly larger than the ulcer surface was pasted on the ulcer surface, 3-4 times/d. Patients in the treatment group were po administered with Zhizi Jinhua Pills on the basis of the control group, 9 g/time, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the symptom scores, serum levels of hs-CRP, IL-6, TNF-α and IL-17, and SF-36 scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.82%, which was significantly lower than 97.26% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the symptom scores in two groups were significantly decreased (P<0.05), and these scores in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the serum levels of hs-CRP, IL-6, TNF-α, and IL-17 in two groups were significantly decreased (P<0.05), and these indexes in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the SF-36 scores in two groups were significantly increased (P<0.05), and which in the treatment group were significantly higher than those in the control group (P<0.05). Conclusion Zhizi Jinhua Pills combined with Compound Gentamycin Pellicles in treatment of recurrent oral mucosal ulcer can significantly improve its clinical symptoms, reduce inflammation and improve the quality of life.