目的 分析2014-2018年解放军第三一六医院妊娠期女性人型支原体和解脲支原体感染状况及耐药性。方法 采用回顾性分析的方法，对2014年1月-2018年12月解放军三一六医院的1 171例妊娠期女性泌尿生殖道支原体感染状况及耐药情况进行分析。结果 1 171例妊娠期女性中，644例感染了解脲支原体和/或人型支原体，其中1人感染了人型支原体，590例感染了解脲支原体，53例共同感染了两种支原体。解脲支原体在17~20岁年龄段感染率最高，解脲支原体和人型支原体双阳性在41~50年龄段感染率最高。解脲支原体和/或人型支原体对喹诺酮类抗生素、阿奇霉素和红霉素的敏感性较低，对交沙霉素、克拉霉素、美满霉素、强力霉素和四环素的敏感性较高。结论 妊娠期女性泌尿生殖道支原体的感染率高，耐药严重，一定要根据培养鉴定和药敏试验选用敏感抗生素进行治疗。

Objective To investigate the prevalence and drug resistance of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women from 316th Hospital of PLA from 2014 to 2018. Methods The prevalence and drug resistance of M. hominis and U. urealyticum in 1 171 pregnant women from January 2014 to December 2018 were analyzed retrospectively. Results A total of 644 instances of M. hominis and/or U. urealyticum were detected. Of them, U. urealyticum was detected in 590 specimens, while M. hominis was detected in only 1 specimen. The remaining 53 specimens were positive for both M. hominis and U. urealyticum. The infection rate of M. urealyticum was the highest in 17-20 years. The infection rate of pathogenic bacteria positive for both M. hominis and U. urealyticum was the highest in 41-50 years. Most of M. hominis and/or U. urealyticum showed low susceptibilities to quinolones, azithromycin, and erythromycin. Most of M. hominis and/or U. urealyticum were susceptible to josamycin, clarithromycin, minamycin, doxycycline, and tetracycline. Conclusion The prevalence of genital mycoplasma infection in pregnant women is high and most of them have a high level of resistance. It is important to identify the isolates and use appropriate antibiotics according to the antibiotic susceptibility tests.