目的 对成都市妇女儿童中心医院门诊左乙拉西坦的使用情况进行分析，为临床合理用药提供参考。方法 收集成都市妇女儿童中心医院门诊2018年包含左乙拉西坦的处方，并进行统计分析；结果 共收集处方172张，4岁以下患儿88例，构成比为51.16%；诊断为癫痫的共144张，构成比为83.72%；172张处方中选用左乙拉西坦口服溶液的有60例；剂量<10 mg/kg的60例，构成比为34.88%；单药治疗的患儿共132例，构成比为76.74%；不合理处方共36张，主要为诊断不合理，构成比为16.28%。结论 成都市妇女儿童中心医院门诊左乙拉西坦的使用在患儿年龄及单药治疗方面存在超说明书用药现象，有循证学依据，但对于这类超说明书用药应当加强管理；剂型选择基本合理；因未及时更新临床诊断，有少数用药与诊断不一致的处方；用法用量基本合理，少数处方的用药频率存在与说明书不一致的现象，建议通过在门诊开展处方前置审核来尽量减少此类处方的出现。

Objective To analyze the use of levetiracetam in outpatient of Chengdu Women and Children's Hospital, so as to provide references for the reasonable application of levetiracetam. Methods The prescriptions which contained levetiracetam were collected and statistically analyzed in outpatient of Chengdu Women and Children's Hospital in 2018. Results 172 Pieces of prescriptions were collected. There were 88 prescriptions for children under 4 years old, accounted for 51.16%. 144 Pieces of prescriptions were diagnosed with epilepsy, accounted for 83.72%. There were 60 children treated with levetiracetam oral solution. 60 Pieces of prescriptions for dosage under 10 mg/kg, accounted for 34.88%. There were 132 cases of children who received levetiracetam monotherapy, accounting for 76.74%. There were 36 cases of unreasonable prescriptions, and most of them were mainly unreasonable diagnose (16.28%). Conclusion The use of levetiracetam in outpatient of Chengdu Women and Children's Hospital has some off-label application in age and levetiracetam monotherapy. The off-lable drug use is based on evidences. It is still necessary to manage the off-lable drug use strengthenly, and the clinical rational levetiracetam use should be promoted. The chose of dosage forms is reasonable mostly. There are a few irrational prescriptions due to the outdated clinical diagnosis. The dosage were reasonable on the wholle, except a few prescriptions not agree with dispensatory in frequency of administration. The irrational prescriptions are prospected to be decreased though pre-prescription review.

成都市科技局科技惠民技术研发项目（2015-HM01-00136-SF）