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目的 探讨复方斑蝥胶囊联合TL方案(紫杉醇+洛铂)治疗宫颈癌的临床疗效。方法 选取2017年1月-2018年8月陆军军医大学第二附属医院收治的100例宫颈癌患者作为研究对象,根据随机数字表法将患者分为对照组和治疗组,每组各50例。对照组患者给予TL方案治疗:第1天静脉滴注注射用紫杉醇脂质体,135 mg/m2加入到5%葡萄糖注射液500 mL中,滴注时间3~4 h;第2天静脉滴注注射用洛铂,30 mg/m2加入到5%葡萄糖注射液500 mL中。3周为1个周期,间隔2周开始下个周期,共治疗2个周期。治疗组患者在对照组治疗的基础上口服复方斑蝥胶囊,0.75 g/次,2次/d,连续治疗8周。观察两组的临床疗效,比较两组的KPS评分、血清肿瘤标志物水平、病理组织侵袭分子情况、病理组织血管生成、毒副反应。结果 治疗后,对照组和治疗组的客观缓解率分别为38.00%、58.00%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者KPS评分明显升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组患者KPS评分明显高于对照组,两组差异有统计学意义(P<0.05)。治疗后,两组患者血清癌胚抗原(CEA)、糖链抗原-125(CA125)、鳞状上皮细胞癌抗原(SCCA)水平显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组患者血清CEA、CA125、SCCA水平明显低于对照组,两组差异有统计学意义(P<0.05)。治疗后,治疗组E-钙黏附蛋白(E-cad)的信使核糖核酸(mRNA)含量、蛋白含量低于对照组,而E盒结合锌指蛋白2(ZEB2)、埃兹蛋白(Ezrin)的mRNA含量、蛋白含量高于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者病灶组织肿瘤微血管密度(MVD)、血管内皮生长因子(VEGF)表达均高于健康组织,两组差异有统计学意义(P<0.05);且治疗组病灶组织MVD、VEGF表达明显低于对照组,两组差异有统计学意义(P<0.05)。治疗后,治疗组骨髓抑制、胃肠道反应、肝功能损害、脱发的发生率明显低于对照组,两组差异有统计学意义(P<0.05)。结论 复方斑蝥胶囊联合TL方案治疗宫颈癌具有较好的临床疗效,能抑制癌细胞血管生成,患者癌细胞侵袭能力降低,安全性较好,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical effect of Compound Banmao Capsules combined with TL regimen in treatment of cervical cancer. Methods Patients (100 cases) with cervical cancer in the Second Affiliated Hospital of Military Medical University from January 2017 to August 2018 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were given TL regimen:patients were iv administered with Paclitaxel Liposome for injection on the first day, 135 mg/m2 added into glucose solution 500 mL, dropping time 3-4 h; and patients were iv administered with Lobaplatin for injection on the second day, 30 mg/m2 added into glucose solution 500 mL. A cycle had 3 weeks, the next cycle begined at two weeks interval, and patients were treated for 2 cycles. Patients in the treatment group were po administered with Compound Banmao Capsules on the basis of the control group, 0.75 g/time, twice daily, and were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and KPS scores, serum level of serum tumor markers, invasive molecules in pathological tissues, angiogenesis in pathological tissues, and adverse reactions in two groups were compared. Results After treatment, the objective remission rate in the control and treatment groups were 38.00% and 58.00%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of CEA, CA125, and SCCA in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the serum level of serum tumor markers in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, mRNA content and protein content of E-cad in the treatment group were lower than those in the control group, but mRNA contents and protein contents of ZEB2 and Ezrin in the treatment group were higher than those in the control group, and there was difference between two groups (P<0.05). After treatment, MVD and VEGF of lesion tissue in two groups were significantly higher than those of healthy tissue in two groups, and the difference was statistically significant in the same group (P<0.05). And the observational indexes of lesion tissue in the treatment group were significantly lower than those of lesion tissue in the control group, with significant difference between two groups (P<0.05). After treatment, the incidence of myelosuppression, gastrointestinal reactions, liver damage, and alopecia in the treatment group were significantly lower than those in the control group, and there was difference between two groups (P<0.05). Conclusion Compound Banmao Capsules combined with TL regimen has clinical curative effect in treatment of cervical cancer, can inhibit the angiogenesis of cancer cells, and reduce the invasive ability of cancer cells in patients, with good safety, which has a certain clinical application value.
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