目的 观察十味消渴胶囊联合沙格列汀治疗2型糖尿病的临床疗效。方法 选取2018年1月-2018年12月天津医科大学朱宪彝纪念医院收治的2型糖尿病患者中选取106例，随机分为对照组和治疗组，每组各53例。对照组口服沙格列汀片，5 mg/次，1次/d；治疗组在对照组治疗基础上口服十味消渴胶囊，6粒/次，3次/d。两组患者均连续治疗12周。观察两组的临床疗，比较两组治疗前后中医症候积分、血糖相关指标和炎症因子水平的变化情况。结果 治疗后，对照组和治疗组的总有效率分别是75.47%、92.45%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者口渴喜饮评分、五心烦热评分、倦怠乏力评分、总评分均较治疗前显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组这些症候评分显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者空腹血糖（FPG）、餐后2 h血糖（2 h PG）、糖化血红蛋白（HbA1c）、空腹胰岛素（Fins）水平均较治疗前显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组这些血糖相关指标显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组高敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）水平均较治疗前显著降低，同组治疗前后比较差异均有统计学意义（P<0.05）；治疗后，治疗组hs-CRP、IL-6水平显著低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 十味消渴胶囊联合沙格列汀治疗2型糖尿病具有较好的临床疗效，可显著降低症状评分，更好的调节血糖相关指标，具有一定的临床推广应用价值。

Objective To observe the clinical effect of Shiwei Xiaoke Capsules combined with saglitine in treatment of type 2 diabetes. Methods Patients (106 cases) with type 2 diabetes in Zhuxianyi Memorial Hospital of Tianjin Medical University from January 2018 to December 2018 were randomly divided into control (53 cases) and treatment (53 cases) groups. Patients in the control group were po administered with Saxagliptin Tablets, 5 mg/time, once daily. Patients in the treatment group were po administered with Shiwei Xiaoke Capsules, 6 grains/time, three times daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacy was evaluated, and the changes of TCM syndrome scores, glycemic indexes and inflammatory factors in two groups were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 75.47% and 92.45%, respectively, and there were differences between two groups (P<0.05). After treatment, thirsty like drinking score, five upset heat score, burnout score, and total score in two groups were significantly decreased, and there were differences in the same group (P<0.05). After treatment, the syndrome scores in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). After treatment, FPG, 2 h PG, HbA1c, and Fins in two groups were significantly decreased, and there were differences in the same group (P<0.05). After treatment, the glycemic indexes in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). After treatment, hs-CRP and IL-6 in two groups were significantly decreased, and there were differences in the same group (P<0.05). After treatment, hs-CRP and IL-6 in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). Conclusion Shiwei Xiaoke Capsules combined with saglitine has good clinical effect in treatment of type 2 diabetes, and can significantly reduce the symptom score, and better regulate blood sugar related indicators, which has a certain clinical application value.

天津医科大学朱宪彝纪念医院科研基金资助项目（2018ZDKF01）