目的 研究小儿健脾开胃合剂联合赖氨酸维B₁₂颗粒治疗小儿厌食症的临床疗效。方法 选取2017年12月-2018年12月青海省妇女儿童医院收治的80例厌食症患儿为研究对象，将所有患儿随机分为对照组和治疗组，每组各40例。对照组患儿口服赖氨酸维B₁₂颗粒，1~5岁，0.5袋/次，2次/d，6~12岁，1袋/次，2次/d；治疗组患儿在对照组治疗的基础上口服小儿健脾开胃合剂，10 mL/次，2次/d。两组患儿持续治疗30 d。观察两组的临床疗效，比较两组的微量元素、生化指标水平。结果 治疗后，对照组和治疗组的总有效率分别为82.50%、95.00%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患儿铁、钙和锌水平均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；并且治疗组患儿铁、钙和锌水平均明显高于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组患儿血红蛋白（Hb）、血清淀粉酶（AMS）、血清铁蛋白（SF）水平均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；并且治疗组患儿Hb、AMS、SF水平明显高于对照组，两组比较差异有统计学意义（P<0.05）。结论 小儿健脾开胃合剂联合赖氨酸维B₁₂颗粒治疗小儿厌食症具有较好的临床疗效，能改善患儿贫血症状，调节血清微量元素水平，具有一定的临床推广应用价值。

Objective To study the effect of Xiaoer Jianpi Kaiwei Mixture combined with Lysine and Vitamin B₁₂ Granules in treatment of anorexia in children. Methods Children (80 cases) with anorexia in Women and Children's Hospital of Qinghai from December 2017 to December 2018 were randomly divided into control and treatment groups, and each group had 40 cases. Children in the control group were po administered with Lysine and Vitamin B₁₂ Granules, 1-5 years old:0.5 bag/time, 6-12 years old:1 bag/time, twice daily. Children in the treatment group were po administered with Xiaoer Jianpi Kaiwei Mixture on the basis of the control group, 10 mL/time, twice daily. Children in two groups were treated for 30 d. After treatment, the clinical efficacies were evaluated, and the level of trace elements and biochemical indicators in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.50% and 95.00%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of Fe, Ca and Zn in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of Hb, AMS and SF in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). Conclusion Xiaoer Jianpi Kaiwei Mixture combined with Lysine and Vitamin B₁₂Granules has clinical curative effect in treatment of anorexia in children, can improve the symptoms of anemia in children, and regulate the serum level of trace elements, which has a certain clinical application value.