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[摘要]
目的 探讨蒲参胶囊联合匹伐他汀钙分散片治疗高脂血症的临床研究。方法 选取2017年7月-2018年9月在许昌市中心医院就诊的90例高脂血症患者为研究对象,所有患者随机分为对照组和治疗组,每组各45例。对照组口服匹伐他汀钙分散片,2 mg/次,1次/d;治疗组在对照组治疗的基础上口服蒲参胶囊,4粒/次,3次/d。两组患者均治疗8周。观察两组的临床疗效,比较两组的血脂水平、炎症因子、内皮功能指标。结果 治疗后,对照组和治疗组的总有效率分别为82.22%、97.78%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者的总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)水平显著降低,高密度脂蛋白胆固醇(HDL-C)水平均显著升高,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组患者的TC、TG、LDL-C、HDL-C水平明显优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者的高敏C反应蛋白(hs-CRP)、白细胞介素-1(IL-1)和白细胞介素-6(IL-6)水平显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组患者的炎症因子水平明显低于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者的内皮素-1(ET-1)水平显著降低,一氧化氮(NO)水平显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组患者的ET-1、NO水平明显优于对照组,两组比较差异有统计学意义(P<0.05)。结论 蒲参胶囊联合匹伐他汀钙分散片治疗高脂血症具有良好的临床疗效,可改善患者血脂水平,抑制氧化应激和炎症反应,保护内皮细胞功能,具有一定临床推广应用价值。
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[Abstract]
Objective To investigate the effects of Pushen Capsules combined with Pitavastatin Calcium Dispersible Tablets in treatment of hyperlipidemia. Methods Patients (90 cases) with hyperlipidemia in Xuchang Central Hospital from July 2017 to September 2018 were randomly divided into control and treatment groups, and each group had 45 cases. Patients in the control group were po administered with Pitavastatin Calcium Dispersible Tablets, 2 mg/time, once daily. Patients in the treatment group were po administered with Pushen Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and blood lipid levels, inflammatory factors, and endothelial function indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.22% and 97.78%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of TC, TG and LDL-C in two groups were significantly decreased, but the levels of HDL-C in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the blood lipid levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of hs-CRP, IL-1, and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the inflammatory factors indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of ET-1 in two groups were significantly decreased, but the levels of NO in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the endothelial function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Pushen Capsules combined with Pitavastatin Calcium Dispersible Tablets has clinical curative effect in treatment of hyperlipidemia, can improve blood lipid level, inhibit oxidative stress and inflammatory reaction, and protect endothelial cell function, which has a certain clinical application value.
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