香菇是药食两用的真菌，香菇多糖是其中的活性代表成分。近年来，香菇多糖在免疫功能调节方面的作用成为研究的热点。研究证实香菇多糖通过刺激机体的免疫器官、促进淋巴细胞的增殖分化、增加NK细胞活性、在基因和分子层次上促进免疫功能的表达，以恢复机体的免疫功能和肿瘤微环境中的免疫平衡，这些因素在抗肿瘤的治疗中体现出巨大的价值。旨在将香菇多糖对肿瘤免疫微环境中的影响及香菇多糖在基因层次调控免疫功能的国内外最近研究进展进行综述，为其在抗肿瘤治疗及其他领域的综合开发提供参考。

Lentinus edodes (Berk.) Sing is a fungus for both medicine and food. Lentinan is the active ingredient that was separated from it. In recent years, the role of lentinan in the regulation of immune function had become a research hotspot. Scientist had confirmed that lentinan could restore the body's immune function and immune balance in the tumor microenvironment by stimulating the body's immune organs, promoting lymphocyte proliferation and differentiation, increasing NK cell activity, and promoting immune function expression at the gene and molecular levels. These factors and reaction were of great value in the treatment of anti-tumor. The purpose of this paper was to induct the recent studies of lentinan on tumor immune microenvironment and the recent research progress of lentinan in gene level regulation of immune function, and provide reference for the comprehensive development of lentinan in anti-tumor therapy and other fields.

R285.5

南通市中医医疗联盟科技项目（TZYK201803）