[关键词]
[摘要]
目的 研究三七脂肝丸联合多烯磷脂酰胆碱胶囊治疗脂肪肝的临床疗效。方法 选取2017年4月-2019年4月涿州市医院收治的140例脂肪肝患者为研究对象,将所有患者随机分为对照组和治疗组,每组各70例。对照组患者口服多烯磷脂酰胆碱胶囊,2粒/次,3次/d;治疗组患者在对照组治疗的基础上口服三七脂肝丸,1袋/次,3次/d。两组患者持续治疗8周。观察两组的临床疗效,比较两组的血脂水平、肝功能指标、血清学指标。结果 治疗后,对照组和治疗组的总有效率分别为81.43%、94.29%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平均明显降低,高密度脂蛋白胆固醇(HDL-C)水平显著增高,同组治疗前后比较差异具有统计学意义(P<0.05);并且治疗组患者TC、LDL-C、HDL-C水平明显优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者天门冬氨酸氨基转氨酶(AST)、丙氨酸氨基转移酶(ALT)和γ-谷氨酰转肽酶(γ-GT)水平显著降低,同组治疗前后比较差异有统计学意义(P<0.05);并且治疗组患者AST、ALT和γ-GT水平明显低于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者成纤维细胞生长因子-21(FGF-21)水平显著降低,血清脂联素(APN)水平显著升高,同组治疗前后比较差异有统计学意义(P<0.05);并且治疗组患者FGF-21和APN水平明显优于对照组,两组比较差异有统计学意义(P<0.05)。结论 三七脂肝丸联合多烯磷脂酰胆碱胶囊治疗脂肪肝具有较好的治疗效果,能改善患者肝功能和血脂水平,调节血清因子水平,安全性较高,值得在临床上推广应用。
[Key word]
[Abstract]
Objective To study the clinical effect of Sanqi Zhigan Pills combined with Polyene Phosphatidylcholine Capsules in treatment of fatty liver. Methods Patients (140 cases) with fatty liver in Zhuozhou City Hospital from April 2017 to April 2019 were randomly divided into control and treatment groups, and each group had 70 cases. Patients in the control group were po administered with Polyene Phosphatidylcholine Capsules, 2 grains/time, three times daily. Patients in the treatment group were po administered with Sanqi Zhigan Pills on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and blood lipid levels, liver function indexes, and serological indicators in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.43% and 94.29%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of TC, and LDL-C in two groups were significantly decreased, but the levels of HDL-C in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the blood lipid levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of AST, ALT, and γ-GT in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the liver function indexes levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of FGF-21 in two groups were significantly decreased, but the levels of APN in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the serological indicators levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Sanqi Zhigan Pills combined with Polyene Phosphatidylcholine Capsules has clinical curative effect in treatment of fatty liver, can improve liver function and blood lipid level, and regulate serum factor level, with good safety, which has a certain clinical application value.
[中图分类号]
R978.7
[基金项目]
保定市科技计划项目(17ZF118)