目的 探讨夏枯草颗粒联合丙硫氧嘧啶片治疗甲状腺功能亢进症的临床疗效。方法 选取2016年9月-2018年3月在喀什地区第一人民医院进行治疗的90例甲状腺功能亢进患者作为研究对象，按照治疗方式分为对照组（47例）和治疗组（43例）。对照组口服丙硫氧嘧啶片，初始剂量为100 mg/次，3次/d，待临床症状和甲状腺功能有所改善后，逐渐减量至50~100 mg/d，后期维持此剂量进行治疗。治疗组在对照组治疗的基础上口服夏枯草颗粒，1袋/次，2次/d。两组患者均连续治疗3个月。观察两组的临床疗效，比较两组的甲状腺功能和骨代谢因子水平。结果 治疗后，对照组和治疗组的总有效率分别为78.72%、93.02%，两组比较差异有统计学意义（P<0.05）。治疗后，两组促甲状腺素（TSH）水平显著升高，游离三碘甲状腺原氨酸（FT3）和游离甲状腺素（FT4）水平均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组甲状腺功能因子水平均显著优于对照组，两组差异具有统计学意义（P<0.05）。治疗后，两组降钙素（CT）、骨钙素（BGP）水平均显著降低，甲状旁腺素（PTH）水平显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组骨代谢因子水平显著优于对照组，两组比较差异均存在统计学意义（P<0.05）。结论 夏枯草颗粒联合丙硫氧嘧啶片治疗甲状腺功能亢进症具有较好临床疗效，能改善甲状腺功能和骨代谢，安全性较好，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Xiakucao Granules combined with Propylthiouracil Tablets in treatment of hyperthyroidism. Methods Patients (90 cases) with hyperthyroidism in the First People's Hospital of Kashi from September 2016 to March 2018 were randomly divided into the control group (47 cases) and the treatment group (43 cases). Patients in the control group were po administered with Propylthiouracil Tablets, starting dosage 100 mg/time, three times daily. Patients in the treatment group were po administered with Xiakucao Granules on the basis of the control group, 1 bag/time, twice daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and thyroid function and the levels of bone metabolism factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 78.72% and 93.02%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of TSH in two groups were significantly increased, but the levels of FT3 and FT4 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the thyroid function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of CT and BGP in two groups were significantly decreased, but the levels of PTH in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the bone metabolism factors levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Xiakucao Granules combined with Propylthiouracil Tablets has clinical curative effect in treatment of hyperthyroidism, can improve thyroid function and bone metabolism, with good safety, which has a certain clinical application value.

R977