目的 探索清热通淋胶囊联合头孢替唑钠治疗泌尿系统感染的临床效果。方法 选择2016年7月-2018年7月武汉市红十字会医院接诊的泌尿系统感染患者178例，按就诊顺序分为对照组（89例）和治疗组（89例）。对照组静脉滴注注射用头孢替唑钠，2.0 g加入生理盐水250 mL，2次/d；治疗组在对照组基础上餐后半小时口服清热通淋胶囊，4粒/次，3次/d。两组患者均持续治疗5 d。观察两组患者临床疗效，同时比较治疗前后两组患者临床症状评分和部分生化指标。结果 治疗后，对照组和治疗组的总有效率分别为76.40%和86.52%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者尿急、尿痛、尿频症状评分均明显降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗后治疗组尿频、尿急、尿痛症状评分均明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者尿白细胞计数、降钙素原和C-反应蛋白水平均显著降低（P<0.05），且治疗组这些生化指标比对照组降低更明显（P<0.05）。结论 清热通淋胶囊联合注射用头孢替唑钠对泌尿系统感染疾病具有良好的治疗效果，具有一定的临床推广应用价值。

Objective To explore the therapeutic effect of Qingre Tonglin Capsules combined with cefotizate sodium in treatment of urinary system infection. Methods Patients (178 cases) with urinary system infection in Wuhan Red Cross Hospital from July 2016 to July 2018 were divided into control (89 cases) and treatment (89 cases) groups based on visiting order. Patients in the control group were iv administered with Ceftezole Sodium for injection, 2 g added into normal saline 250 mL, twice daily. Patients in the treatment group were po administered with Qingre Tonglin Capsules on the basis of the control group 30 min after meal, 4 grains/time, three times daily. Patients in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, and the clinical symptoms scores, the biochemical indicators in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 76.40% and 86.52%, respectively, and there were differences between two groups (P<0.05). After treatment, urgency score, pain score and urination frequency score in two groups were significantly decreased, and there were differences in the same group (P<0.05). After treatment, urgency score, pain score and urination frequency score in the treatment group were significantly lower than those in the control group, and there were differences between two groups (P<0.05). After treatment, the urine leukocyte count, procalcitonin and C-reactive protein levels in two groups were significantly decreased (P<0.05), and the biochemical indicators in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Qingre Tonglin Capsules combined with cefotizate sodium has good therapeutic effect in treatment of urinary system infection, which has a certain clinical application value.

R983