目的 探讨十味龙胆花颗粒联合盐酸左氧氟沙星片治疗社区获得性肺炎的临床疗效。方法 选取2016年2月-2018年5月于鄂东医疗集团黄石市中心医院收治的156例社区获得性肺炎患者作为研究对象，全部患者按照随机原则分为对照组和治疗组，每组各78例。对照组口服盐酸左氧氟沙星片，0.2 g/次，2次/d。治疗组在对照组治疗的基础上口服十味龙胆花颗粒，3 g/次，3次/d。两组患者均治疗7 d。观察两组的临床疗效，比较两组的临床症状改善情况、血清指标。结果 治疗后，对照组和治疗组的总有效率分别为84.62%、94.87%，两组比较差异有统计学意义（P<0.05）。治疗后，治疗组患者发热、咳痰、气促、肺部啰音消失时间均明显短于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者的肿瘤坏死因子-α（TNF-α）、白细胞计数（WBC）、血管内皮生长因子（VEGF）、基质金属蛋白酶-9（MMP-9）水平均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗后治疗组TNF-α、WBC、VEGF、MMP-9水平明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 十味龙胆花颗粒联合盐酸左氧氟沙星片治疗社区获得性肺炎具有较好的临床疗效，可缩短临床症状恢复时间，降低患者炎症反应，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Shiwei Longdanhua Granules combined with Levofloxacin Hydrochloride Tablets in treatment of community acquired pneumonia. Methods Patients (156 cases) with community acquired pneumonia in Huangshi Central Hospital of Edong Healthcare Group from February 2016 to May 2015 were randomly divided into control and treatment groups, and each group had 78 cases. Patients in the control group were po administered with Levofloxacin Hydrochloride Tablets, 0.2 g/time, twice daily. Patients in the treatment group were po administered with Shiwei Longdanhua Granules on the basis of the control group, 3 g/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and clinical symptoms improvement and serum indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 84.62% and 94.87%, respectively, and there was difference between two groups (P<0.05). After treatment, the disappearance times of fever, expectoration, shortness of breath, and lung rales in the treatment group were significantly shorter than those in the control group, and there was difference between two groups (P<0.05). After treatment, the levels of TNF-α, WBC, VEGF, and MMP-9 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the serum indexes levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Shiwei Longdanhua Granules combined with Levofloxacin Hydrochloride Tablets has clinical curative effect in treatment of community acquired pneumonia, can shorten the recovery time of clinical symptoms, and reduce the inflammatory reaction of patients, which has a certain clinical application value.

R974