目的 探讨桉柠蒎肠溶软胶囊联合多索茶碱治疗慢性阻塞性肺疾病急性发作的临床效果。方法 选取2017年1月-2018年6月濮阳市安阳地区医院收治的慢性阻塞性肺疾病急性发作患者108例，随机分成对照组（54例）和治疗组（54例）。对照组静脉滴注多索茶碱注射液，0.2 g加入100 mL葡萄糖液，1次/d。治疗组在对照组基础上餐前0.5 h口服桉柠蒎肠溶软胶囊，1粒/次，3次/d。两组患者连续治疗10 d。观察两组患者临床疗效，同时比较治疗前后两组患者主要症状体征缓解时间、肺功能、血气分析指标及呼出气冷凝液中白三烯B4（LTB4）、白介素-6（IL-6）浓度和血清C反应蛋白（CRP）水平。结果 治疗后，对照组和治疗组临床总有效率分别为85.2%和96.3%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组患者咳嗽、咳痰、气短、肺部哮鸣音的缓解时间较对照组患者均显著缩短（P<0.05）。治疗后，两组患者第1秒用力呼气容积占预计值百分比（FEV1% pred）、FEV1/用力肺活量（FVC）、每分钟最大通气量占预计值百分比（MVV% pred）和动脉血氧分压（pO₂）值显著升高（P<0.05），动脉二氧化碳分压（pCO₂）值显著降低（P<0.05），且治疗组患者这些肺功能和血气分析指标明显好于对照组（P<0.05）。治疗后，两组呼出气冷凝液中LTB4、IL-6水平及血清CRP浓度显著下降（P<0.05），且治疗组患者这些肺功能和血气分析指标明显低于对照组（P<0.05）。结论 桉柠蒎肠溶软胶囊联合多索茶碱治疗慢性阻塞性肺疾病急性发作可明显缓解患者症状，改善肺功能和动脉血气状态，且患者耐受性良好。

Objective To investigate the clinical effect of Eucalyptol, Limonene and Pinene Enteric Soft Capsules combined with doxofylline in treatment of acute attack of chronic obstructive pulmonary disease. Methods Patients (108 cases) with acute attack of chronic obstructive pulmonary disease in Anyang District Hospital from Januaryr 2017 to June 2018 were randomly divided into control (54 cases) and treatment (54 cases) groups. Patients in the control group were iv administered with Doxofylline Injection, 0.2 g added into 100 mL glucose injection, once daily. Patients in the treatment group were po administered with Eucalyptol, Limonene and Pinene Enteric Soft Capsules on the basis of the control group 30 minutes before meal, 4 grain/time, three times daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacy was evaluated, and the remission time of main symptoms and signs, the pulmonary function and blood gas analysis indexes, LTB4, IL-6 concentration in exhaled gas condensate and serum CRP levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 85.2% and 96.3% respectively, and there were differences between two groups (P<0.05). After treatment, the remission time of cough, sputum, shortness of breath, wheezing in the lungs in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment, the FEV1%pred, FEV1/FVC, MVV%pred and pO₂ in two groups were significantly increased (P<0.05), pCO₂ was significantly decreased (P<0.05), and the pulmonary function and blood gas analysis indexes in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the LTB4 and IL-6 levels of the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Eucalyptol, Limonene and Pinene Enteric Soft Capsules combined with doxofylline in treatment of acute attack of chronic obstructive pulmonary disease can significantly relieve symptoms, improve pulmonary function and arterial blood gas status, and the patients have good tolerance.

R974