目的 探讨雪胆素胶囊联合头孢丙烯治疗急性扁桃体炎的临床疗效。方法 选取2018年6月-2019年5月在海南医学院第一附属医院就诊的172例急性扁桃体炎患者，根据用药的差别分为对照组和治疗组，每组各86例。对照组患者口服头孢丙烯片，2片/次，1次/d；治疗组在对照组治疗基础上口服雪胆素胶囊，2粒/次，2次/d。两组均连续治疗7 d。观察两组的临床疗效，比较两组治疗前后症状改善时间、相关积分、血清学指标的变化情况。结果 治疗后，对照组和治疗组的总有效率分别是83.72%、98.83%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组咽痛消失时间、退热时间和扁桃体缩小时间均显著短于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组VAS评分、FPS-R评分、PSQI评分均较治疗前显著降低，而QLQ-C30评分显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组VAS评分、FPS-R评分、PSQI评分显著低于对照组，而QLQ-C30评分高于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清超敏C反应蛋白（hs-CRP）、降钙素原（PCT）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、白细胞介素-17（IL-17）水平均较治疗前显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组这些血清学指标显著低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 雪胆素胶囊联合头孢丙烯治疗急性扁桃体炎具有较好的临床疗效，可有效改善患者临床症状，降低机体炎症反应，减轻疼痛，有助于患者生活质量及睡眠质量的提高，具有一定的临床推广应用价值。

Objective To explore the clinical effect of Xuedansu Capsules combined with cefprozil in treatment of acute tonsillitis. Methods Patients (172 cases) with acute tonsillitis in the First Affiliated Hospital of Hainan Medical College were divided into control (86 cases) and treatment (86 cases) groups according to different medication regimens. Patients in the control group were po administered with Cefprozil Tablets, 2 tablets/time, once daily. Patients in the treatment group were po administered with Xuedansu Capsules on the basis of the control group, 2 grains/time, twice daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the changes of symptom improvement time, correlation scores, and serological indexes in two groups were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 83.72% and 98.83%, respectively, and there were differences between two groups (P<0.05). After treatment, the disappearance time of pharyngeal pain, antipyretic time and tonsillar contraction time in the treatment group were significantly shorter than those in the control group, and there were differences between two groups (P<0.05). After treatment, VAS score, FPS-R score, and PSQI score in two groups were significantly decreased, but QLQ-C30 score was significantly increased, and there were differences in the same group (P<0.05). After treatment, VAS score, FPS-R score, and PSQI score in the treatment group were significantly lower than those in the control group, but QLQ-C30 score was significantly higher than that in the control group, and there were differences between two groups (P<0.05). After treatment, hs-CRP, PCT, IL-6, TNF-α, and IL-17 in two groups were significantly decreased, and there were differences in the same group (P<0.05). After treatment, these serological indexes in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). Conclusion Xuedansu Capsules combined with cefprozil has significant effect in treatment of acute tonsillitis, and can effectively improve patients' clinical symptoms, and reduce the inflammatory response and pain, and contribute to the improvement of life quality and sleep quality, which has a certain clinical application value.

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