压力性损伤是临床常见并发症之一，由压力、剪切力和摩擦力与多种内外因素共同作用下以皮肤、肌肉和皮下组织局限性损伤或坏死为特征的损伤。其病因复杂，且易反复发作。目前临床上专用于压力性损伤的药物很少，基于新药临床研究的高失败率，在老药的原适应症以外开发新用途，寻找现有药物的新适应症已成为极具吸引力的新策略，因此，从治疗压力性损伤新适应症药物角度，对其临床相关药物的研究进展进行系统归纳总结，以期为其临床治疗提供参考。

Pressure injury is one of the common complication in clinic which is characterized as the tissue damage or necrosis in skin, muscles and subcutaneous tissue induced by the pressure, shear, friction, and various internal and external factors. The etiology of pressure injury is complex and easy to relapse. Now, there are few drugs for treatment of pressure injury in clinic. However, it is an attractive strategy to look for some new indications of conventional drug, basing on the high failure rate of studying new drugs. Therefore, the research progress on the new indications of conventional drug including the clinical or pre-clinical is systematically summarized in this paper, in order to provide reference for the clinical treatment of pressure injury.

国家自然科学基金青年项目（81701838）；国家博士后面上项目（2018M632628）；青岛市博士后应用项目