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[摘要]
目的 探究黄体酮软胶囊联合醋酸阿托西班注射液治疗先兆早产的临床疗效。方法 选取2016年2月—2018年1月广元市第一人民医院收治的先兆早产患者130例为研究对象,对照组首次静脉推注醋酸阿托西班注射液6.75 mg,而后静脉滴注醋酸阿托西班注射液,150 mg加入到生理盐水180 mL中,300 μg/min持续3 h,随后100 μg/min直至达到预期抑制宫缩效果。治疗组在对照组治疗的基础上口服黄体酮软胶囊,100 mg/次,2次/d,连续治疗10 d。观察两组的临床疗效,比较两组的药物显效时间、延长孕期时间、血清因子水平和新生儿结局。结果 治疗48 h后,对照组和治疗组的有效率分别为84.62%、95.38%;治疗10 d后,对照组和治疗组的有效率分别为73.85%、87.69%,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组药物显效时间显著低于对照组,延长孕期时间显著高于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组血清促肾上腺皮质激素释放激素(CRH)、白细胞介素-6(IL-6)、前列腺素E2(PGE2)水平均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组血清因子水平明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组Apgar评分、体质量和存活率均显著高于对照组,两组比较差异有统计学意义(P<0.05)。结论 黄体酮软胶囊联合醋酸阿托西班注射液治疗先兆早产具有较好的临床疗效,能延长妊娠时间,调节血清CRH、IL-6、PGE2水平,改善新生儿结局,具有一定临床推广应用价值。
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[Abstract]
Objective To investigate the clinical efficacy of Progesterone Soft Capsules combined with Atosiban Acetate Injection in treatment of threatened preterm labor. Methods Patients (130 cases) with threatened preterm labor in the First People's Hospital of Guangyuan from February 2016 to January 2018 were randomly divided into control and treatment groups, and each group had 65 cases. Patients in the control group were intravenous injection administered with Atosiban Acetate Injection 6.75 mg, then changed to intravenous drip, 150 mg added into normal saline 180 mL, 300 μg/min continued for 3 h, followed by 100 μg/min until the desired effect of inhibiting uterine contraction. Patients in the treatment group were po administered with Progesterone Soft Capsules on the basis of the control group, 100 mg/time, twice daily, treated for 10 d. After treatment, the clinical efficacies were evaluated, and the time of drug effect and pregnancy extension, the level of serum factors, and neonatal outcomes in two groups were compared. Results After treatment for 48 h and 10 d, the clinical efficacies in the control and treatment groups were 84.62%, 95.38%, and 73.85%, 87.69%, respectively, and there was difference between two groups (P < 0.05). After treatment, the time of drug effect in the treatment group was significantly lower than that in the control group, but the time of pregnancy extension in the treatment group was significantly higher than that in the control group, and there were difference between two groups (P < 0.05). After treatment, the levels of CRH, IL-6, and PGE2 in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the serum factors levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, Apgar score, body weight, and survival rate in the treatment group was significantly higher than those in the control group, and there was difference between two groups (P < 0.05). Conclusion Progesterone Soft Capsules combined with Atosiban Acetate Injection has clinical curative effect in treatment of threatened preterm labor, can prolong the time of pregnancy, regulate the levels of CRH, IL-6, and PGE2, can improve neonatal outcomes, which has a certain clinical application value.
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