目的 观察丹参川芎嗪注射液联合奥曲肽治疗急性胰腺炎的临床疗效。方法 选取天津市东丽区东丽医院2014年6月—2017年6月收治的急性胰腺炎患者96例，随机分为对照组和治疗组，每组各48例。对照组静脉注射醋酸奥曲肽注射液，0.2 mg加入20 mL生理盐水中，1次/8 h，3次/d。治疗组在对照组的基础上静脉滴注丹参川芎嗪注射液，10 mL加入250 mL生理盐水中，20～30滴/min，1次/d。两组均连续治疗2周。观察两组的临床疗效，比较两组临床症状及相关实验室指标、血清炎症因子、血浆因子和免疫细胞水平以及并发症情况。结果 治疗后，对照组和治疗组的总有效率分别为72.91%、91.67%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组各项临床症状及相关实验室检查指标恢复时间均显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组前列环素（PGI2）、血栓素A2（TXA2）/PGI2的比值（T/P）水平均显著升高，而TXA2水平则显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；同时治疗后治疗组上述血浆因子水平显著优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平均显著降低，而IL-10、CD4⁺、CD8⁺和CD4⁺/CD8⁺水平则显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；同时治疗后治疗组上述血清炎症因子、免疫细胞水平均显著优于对照组，两组比较差异具有统计学意义（P<0.05）。对照组和治疗组并发症的发生率分别为33.33%、15.58%，两组比较差异具统计学意义（P<0.05）。结论 丹参川芎嗪注射液联合奥曲肽治疗急性胰腺炎疗效确切，能够明显调节患者免疫功能，改善机体炎症状态，促进肠道功能恢复，且并发症发生率较低，值得临床推广。

Objective To observe the clinical effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with octreotide in treatment of acute pancreatitis. Methods Patients (96 cases) with acute pancreatitis in Dongli Hospital of Dongli District in Tianjin from June 2014 to June 2017 were randomly divided into control and treatment groups, and each group had 48 cases. Patients in the control group were iv administered with Octreotide Acetate Injection, 0.2 mg added into normal saline 20 mL, once per 8 h, three times daily. Patients in the treatment group were iv administered with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on the basis of the control group, 10 mL added into normal saline 250 mL, 20-30 drops/min, once daily. Patients in two groups were treated for two weeks. After treatment, the clinical efficacy was evaluated, and clinical symptoms and related laboratory indicators, serum inflammation factors, plasma factors, immune cells, and complications in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 72.91% and 91.67%, respectively, and there was difference between two groups (P < 0.05). After treatment, the clinical symptoms and related laboratory indicators in the treatment group were lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, PGI2 and T/P in two groups were significantly increased, but the TXA2 levels were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And those plasma factors in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, IL-6 and TNF-α in two groups were significantly decreased, but IL-10, CD4⁺, CD8⁺, and CD4⁺/CD8⁺ were significantly increased, there were differences in the same group (P < 0.05). And serum inflammation factors and immune cells in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). The complication rate in the control and treatment groups were 33.33% and 15.58%, respectively, and there was difference between two groups (P < 0.05). Conclusion Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with octreotide has significant curative effect in treatment of acute pancreatitis, which can effectively adjust the patient's immune function, improve the body's inflammatory state, and promote the recovery of intestinal function with low complication rate, which has a certain clinical application value.