目的 探讨胆石片联合头孢唑林钠治疗慢性胆囊炎的临床疗效。方法 选取2017年2月—2017年11月在成都市龙泉驿区第一人民医院治疗的慢性胆囊炎患者94例，随机分为对照组（47例）和治疗组（47例）。对照组静脉滴注注射用头孢唑林钠，2.0 g加入生理盐水100 mL，2次/d；治疗组在对照组基础上口服胆石片，3 g/次，3次/d。两组均治疗14 d。观察两组患者临床疗效，同时比较治疗前后两组患者临床症状评分、Mc Gill量表评分、胆囊收缩功能、胆囊壁厚度和血清学指标。结果 治疗后，对照组和治疗组临床有效率分别为80.85%和95.74%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者中医证候评分和Mc Gill量表评分均显著降低（P<0.05），且治疗组评分明显低于对照组（P<0.05）。治疗后，两组胆囊收缩功能显著增强（P<0.05），胆囊壁厚度显著降低（P<0.05），且治疗组胆囊收缩功能和胆囊壁厚度明显优于对照组（P<0.05）。治疗后，两组患者血清白细胞介素-6（IL-6）、β-内啡肽（β-EP）、肿瘤坏死因子-α（TNF-α）水平均明显降低（P<0.05），白细胞介素-2（IL-2）水平明显升高（P<0.05），且治疗后治疗组上述血清学指标明显优于对照组（P<0.05）。结论 胆石片联合头孢唑林钠治疗慢性胆囊炎不仅可以改善其临床症状、降低机体炎症反应，还可有效改善胆囊功能。

Objective To evaluate the clinical efficacy of Danshi Tablets combined with cefazolin sodium in treatment of chronic cholecystitis. Methods Patients (94 cases) with chronic cholecystitis in the First People's Hospital of Longquanyi District from February 2017 to November 2017 were randomly divided into control (47 cases) and treatment (47 cases) groups. Patients in the control group were iv administered with Cefazolin Sodium for injection, 2.0 g added into normal saline 100 mL, twice daily. Patients in the treatment group were po administered with Danshi Tablets on the basis of the control group, 3 g/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the clinical symptom scores, the Mc Gill scales, the gallbladder contraction function, thickness of gallbladder wall and the serological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 80.85% and 95.74% respectively, and there were differences between two groups (P < 0.05). After treatment, the TCM syndrome and Mc Gill scales scores in two groups were significantly decreased (P < 0.05), and these scores in the treatment group after treatment were significantly lower than that in the control group (P < 0.05). After treatment, the gallbladder contraction function in two groups was significantly enhanced (P < 0.05), the thickness of gallbladder wall was significantly decreased (P < 0.05), and the improvement of the gallbladder contraction function and thickness of gallbladder wall in the treatment group after treatment were significantly better than those in the control group (P < 0.05). After treatment, the IL-6, LEP and TNF-α levels in two groups were significantly decreased (P < 0.05), IL-2 levels were significantly increased (P < 0.05), and the serological indexes in the treatment group after treatment were significantly better than those in the control group (P < 0.05). Conclusion Danshi Tablets combined with cefazolin sodium has good effect in treatment of chronic cholecystitis, and can improve the clinical symptoms and reduce the inflammatory reaction, and can effectively improve the gallbladder function.