目的 研究芪参胶囊联合富马酸比索洛尔片治疗冠心病心绞痛的临床疗效。方法 选取2014年8月—2017年8月中国医科大学附属第四医院收治的冠心病心绞痛患者100例为研究对象，将所有患者随机分为对照组和治疗组，每组各50例。对照组口服富马酸比索洛尔片，1片/次，1次/d。治疗组在对照组治疗的基础上口服芪参胶囊，3粒/次，3次/d，温开水送下。两组患者均持续治疗28 d。观察两组的临床疗效和心电图疗效，比较两组的心绞痛发作情况、血液流变学指标水平和血清细胞因子水平。结果 治疗后，对照组和治疗组患者的总有效率分别为84.00%、96.00%，两组比较差异有统计学意义（P<0.05）。治疗后，对照组和治疗组患者的心电图疗效总有效率分别为80.00%、92.00%，两组比较差异有统计学意义（P<0.05）。治疗后，两组心绞痛发作次数和持续时间显著下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组心绞痛发作情况明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组全血黏度（WBV）、血浆黏度（PV）和纤维蛋白原（FIB）水平均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组血液流变学指标水平明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组细胞因子水平明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 芪参胶囊联合富马酸比索洛尔片治疗冠心病心绞痛具有较好的临床疗效，能改善患者临床症状，调节血液流变学指标和血清炎性因子水平，安全性较好，具有一定的临床推广应用价值。

Objective To study the clinical effect of Qishen Capsules combined with Bisoprolol Fumarate Tablets in treatment of angina pectoris of coronary heart disease. Methods Patients (100 cases) with angina pectoris of coronary heart disease in the Fourth Affiliated Hospital of China Medical University from August 2014 to August 2017 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Bisoprolol Fumarate Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Qishen Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 28 d. After treatment, the clinical efficacies and electrocardiogram efficacies were evaluated, and attack of angina pectoris, blood rheology indexes, and serum cytokine levels in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 84.00% and 96.00%, respectively, and there was difference between two groups (P < 0.05). After treatment, the electrocardiogram efficacies in the control and treatment groups were 80.00% and 92.00%, respectively, and there was difference between two groups (P < 0.05). After treatment, the frequency and duration of angina pectoris in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the attacks of angina pectoris indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of WBV, PV, and FIB in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the blood rheology indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of hs-CRP, IL-6, and TNF-α in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the serum cytokine levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Qishen Capsules combined with Bisoprolol Fumarate Tablets has clinical curative effect in treatment of angina pectoris of coronary heart disease, can improve clinical symptoms, regulate blood rheology indexes and serum cytokine levels, with good safety, which has a certain clinical application value.