目的 探讨复方脑肽节苷脂联合盐酸多奈哌齐治疗阿尔茨海默症患者的临床疗效。方法 选取2016年7月—2017年7月在首都医科大学附属北京康复医院治疗的阿尔茨海默症患者105例，随机分成对照组（52例）和治疗组（53例）。对照组患者口服盐酸多奈哌齐片，1片/次，1次/d。治疗组患者在对照组的基础上静脉滴注复方脑肽节苷脂注射液，10 mL加入300 mL生理盐水，1次/d。两组患者均治疗2周。观察两组患者临床疗效，同时比较治疗前后两组患者精神状态、生活自理能力、阿尔茨海默相关的神经丝蛋白（AD7C-NTP）和tau蛋白水平。结果 治疗后，对照组和治疗组的总有效率分别为78.85%和94.34%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者MMSEE评分和BI指数均显著升高（P<0.05），且治疗后治疗组患者精神状态和生活自理能力明显优于对照组（P<0.05）。治疗后，两组患者AD7c-NTP和tau蛋白水平均显著降低（P<0.05），且治疗后治疗组患者AD7c-NTP和tau蛋白水平明显低于对照组（P<0.05）。结论 复方脑肽节苷脂联合盐酸多奈哌齐治疗阿尔茨海默症患者疗效显著，安全性高，具有一定的临床推广应用价值。

Objective To explore the clinical efficacy of compound porcine cerebroside and ganglioside combined with donepezil in treatment of Alzheimer's disease. Methods Patients (105 cases) with Alzheimer's disease in Beijing Rehabilitation Hospital of Capital Medical University from July 2016 to July 2017 were randomly divided into control (52 cases) and treatment (53 cases) groups. Patients in the control group were po administered with Donepezil Hydrochloride Tablets, 1 tablet/time, once daily. Patients in the treatment group were iv administered with Compound Porcine Cerebroside and Ganglioside Injection on the basis of the control group, 10 mL added into normal saline 300 mL, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the mental status, self-care ability, the AD7c-NTP and tau protein levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 78.85% and 94.34% respectively, and there were differences between two groups (P < 0.05). After treatment, the MMSEE scores and BI indexes in two groups were significantly increased (P < 0.05), and the mental status and self-care ability in the treatment group after treatment were significantly better than those in the control group (P < 0.05). After treatment, the AD7c-NTP and tau levels in two groups were significantly decreased (P < 0.05), and the AD7c-NTP and tau levels in the treatment group after treatment were significantly lower than those in the control group (P < 0.05). Conclusion Compound porcine cerebroside and ganglioside combined with donepezil has significant clinical effect in treatment of Alzheimer's disease with high safety, which has a certain clinical application value.