目的 探讨脑血疏口服液联合甘油果糖治疗脑出血的临床疗效。方法 选取2017年2月—2018年1月在洛阳市第一人民医院进行治疗的76例脑出血患者为研究对象，根据用药的差别分为对照组和治疗组，每组各38例。对照组静脉滴注甘油果糖氯化钠注射液500 mL/次，每次1～1.5 h，2次/d；治疗组在对照组治疗基础上口服脑血疏口服液，10 mL/次，3次/d。两组均经过4周治疗后进行效果比较。观察两组的临床疗效，比较两组治疗前后NIHSS评分、血肿量、周围水肿量、相关临床指标、脑灌注参数、血清学指标的变化情况。结果 治疗后，对照组和治疗组的总有效率分别为81.58%、97.37%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者NIHSS评分、血肿量、周围水肿量、平均通过时间（MTT）较治疗前均明显降低，脑血流量（rCBF）、相对脑血容量（rCBV）显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组NIHSS评分、血肿量、周围水肿量、MTT均明显小于对照组，rCBF、rCBV显著高于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清超敏C反应蛋白（hs-CRP）、基质金属蛋白酶-9（MMP-9）、白细胞介素-1β（IL-1β）水平均降低，而胰岛素样生长因子-1（IGF-1）水平均增高，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，hs-CRP、MMP-9、IL-1β水平低于对照组，IGF-1水平高于对照组，两组比较差异具有统计学意义（P<0.05）。结论 脑血疏口服液联合甘油果糖治疗脑出血具有较好的临床疗效，可有效改善患者神经功能，有利于减轻血肿周围组织低灌注损伤，促进血肿吸收，改善机体炎症反应，具有一定的临床推广应用价值。

Objective To explore the clinical effect of Naoxueshu Oral Liquid combined with glycerol fructose in treatment of cerebral hemorrhage. Methods Patients (76 cases) with cerebral hemorrhage in the First People's Hospital of Luoyang February 2017 to January 2018 were divided into control (38 cases) and treatment (38 cases) groups according to the difference of treatment. Patients in the control group were iv administered with Glycerol Fructose and Sodium Chloride Injection, 500 mL/time, 1-1.5 h each time, twice daily. Patients in the treatment group were po administered with Naoxueshu Oral Liquidn on the basis of the control group, 10 mL/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the changes of NIHSS score, hematoma volume, peripheral edema volume, related clinical indicators, cerebral perfusion parameters, and serological indicators in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment group were 81.58% and 97.37%, and there were differences between two groups (P < 0.05). After treatment, NIHSS score, hematoma volume, peripheral edema volume, and MTT were significantly decreased in two groups, but rCBF and rCBV were significantly increased, and there were differences in the same group (P < 0.05). After treatment, NIHSS score, hematoma volume, peripheral edema volume, and MTT in the treatment group, were lower than those in the control group, but rCBF and rCBV were higher than those in the control group, and there were differences between two groups (P < 0.05). After treatment, hs-CRP, MMP-9, and IL-1β were significantly decreased in two groups, but IGF-1 was significantly increased, and there were differences in the same group (P < 0.05). After treatment, hs-CRP, MMP-9, and IL-1β in the treatment group were lower than those in the control group, but IGF-1 was higher than those in the control group, and there were differences between two groups (P < 0.05). Conclusion Naoxueshu Oral Liquid combined with glycerol fructose has significant clinical effect in treatment of cerebral hemorrhage, and can effectively improve nerve function, and reduce the damage of hypoperfusion around the hematoma, also can promote the absorption of hematoma and improve the inflammatory response, which has a certain clinical application value.