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[摘要]
目的 探讨葛酮通络胶囊联合尤瑞克林治疗急性脑梗死的临床效果。方法 选取2015年3月—2018年3月海南省人民医院收治的122例急性脑梗死患者,随机分为对照组和治疗组,每组各61例。对照组静脉滴注注射用尤瑞克林,0.15 PNA单位加入生理盐水100 mL中均匀混合后给药,1次/d。治疗组在对照组治疗基础上口服葛酮通络胶囊,2粒/次,2次/d。两组均连续治疗2周。观察两组的临床疗效,比较两组治疗前后NIHSS评分、血浆黏度(PV)、血沉(ESR)、平均血小板体积(MPV)、血小板分布宽度(PDW)、舒张末期血流速度(Vd)、收缩期峰值血流速度(Vs)及平均血流速度(Vm)、丙二醛(MDA)、超氧化物歧化酶(SOD)、一氧化氮(NO)、内皮素-1(ET-1)的变化情况。结果 治疗后,对照组和治疗组的总有效率分别为78.7%、91.8%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组NIHSS评分、PV、ESR、MPV、PDW值较治疗前均显著降低,两组Vd、Vs、Vm值较治疗前均显著升高,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组NIHSS评分、PV、ESR、MPV、PDW显著低于对照组,治疗组Vd、Vs、Vm值显著高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血清MDA、ET-1水平均显著降低,但血清SOD、NO水平均显著升高,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组血清MDA、ET-1水平显著低于对照组,血清SOD、NO水平显著高于对照组,两组比较差异具有统计学意义(P<0.05)。结论 葛酮通络胶囊联合尤瑞克林治疗急性脑梗死具有较好的临床疗效,能明显减轻患者神经功能缺损,改善血流变状态,调节血小板功能,提高局部脑血流量,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical effects of Getong Tongluo Capsules combined with urinary kallidinogenase in treatment of acute cerebral infarction. Methods Patients (122 cases) with acute cerebral infarction in Hainan General Hospital from March 2015 to March 2018 were randomly divided into control (61 cases) and treatment (61 cases) groups. Patients in the control group were iv administered with Urinary Kallidinogenase for injection, 0.15 PNA U evenly mixed with normal saline100 mL, once daily. Patients in the treatment group were po administered with Getong Tongluo Capsules on the basis of the control group, 2 grains/time, twice daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the changes of NIHSS score, PV, ESR, MPV, PDW, Vd, Vs, Vm, MDA, SOD, NO, and ET-1 in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment group were 78.7% and 91.8%, and there were differences between two groups (P < 0.05). After treatment, NIHSS score, PV, ESR, MPV, and PDW in two groups were significantly decreased, but Vd, Vs, and Vm in were significantly increased, and there were differences in the same group (P < 0.05). After treatment, NIHSS score, PV, ESR, MPV, and PDW in the treatment group were lower than those in the control group, but Vd, Vs, and Vm were higher than those in the control group, and there were differences between two groups (P < 0.05). After treatment, MDA and ET-1 in two groups were significantly decreased, but SOD and NO were significantly increased, and there were differences in the same group (P < 0.05). After treatment, MDA and ET-1 in the treatment group were lower than those in the control group, but SOD and NO were higher than those in the control group, and there were differences between two groups (P < 0.05). Conclusion Getong Tongluo Capsules combined with urinary kallidinogenase has significant clinical effect in treatment of acute cerebral infarction, and can significantly reduce the neurological deficit, and improve the state of blood rheology, also can regulate the function of platelets, and improve the local cerebral blood flow, which has a certain clinical application value.
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