目的 分析西安市中心医院质子泵抑制剂（PPIs）的使用情况和用药趋势，为临床合理用药提供参考。方法 调取2014-2016年西安市中心医院PPIs的相关信息，对品种、用量、销售金额、用药频度（DDDs）、日均费用（DDC）及药品排序比（B/A）进行回顾性分析。结果 PPIs的销售金额和DDDs总体呈逐年递增趋势；销售金额排名前3位的科室是消化内科、普外科和血液科，各科室品种选择呈逐年多样化；销售金额和DDDs连续3年排第1位的品种分别是注射用兰索拉唑、雷贝拉唑肠溶片；各品种PPIs的DDC趋于稳定；B/A连续3年为1.00的是注射用泮托拉唑、艾司奥美拉唑肠溶片。结论 西安市中心医院PPIs的应用仍存在不合理用药现象，各部门需加强协作，提高合理用药水平，确保患者用药安全、经济、有效。

Objective To analyze the situation and developing trend of proton pump inhibitors (PPIs) in Xi'an Central Hospital, and to provide a reference for rational drug use in clinic. Methods Clinical data of PPIs were collected in Xi'an Central Hospital from 2014 to 2016, and the varieties, amount, consumption sum, defined daily doses (DDDs), defined daily cost (DDC) and drug sequence ratio (B/A) were analyzed retrospectively. Results Consumption sum and DDDs of PPIs showed an increasing trend year by year. Department with top 3 consumption sum of PPIs were Department of Gastroenterology, General surgery, and Hematology. The variety choice of PPIs was diversified year by year. Consumption sum and DDDs of Lansoprazole Injection and Rabeprazole Enteric-coated Tablets ranked consecutive the first. DDC of PPIs tended to be stable. Pantoprazole for injection and Esomeprazole Enteric-coated Tablets of B/A was 1.00 for three consecutive years. Conclusion The irrational use of PPIs in Xi'an Central Hospital still exists. The departments should strengthen cooperation, raise the level of rational use of PPIs, and ensure the safety, economy and effectiveness of the medication.