目的 探讨盐酸氨基葡萄糖胶囊联合复方骨肽注射液治疗膝骨关节炎的临床效果。方法 选取2016年1月-2018年1月湘西土家族苗族自治州人民医院收治的114例膝骨关节炎患者，随机分为对照组和治疗组，每组各57例。对照组静脉滴注复方骨肽注射液，10 mL用250 mL等渗盐水充分稀释后给药，1次/d。治疗组在对照组治疗基础上口服盐酸氨基葡萄糖胶囊，2粒/次，3次/d。两组均连续治疗4周。观察两组的临床疗效，比较两组治疗前后西安大略和麦克马斯特大学（WOMAC）量表评分、膝关节高频超声参数、白介素（IL）-1β、基质金属蛋白酶（MMP）-3、软骨寡聚基质蛋白（COMP）、蛋白聚糖（PG）水平的变化情况。结果 治疗后，对照组和治疗组的总有效率分别为77.2%、91.2%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组疼痛评分、僵硬评分、关节功能评分及总分较治疗前均显著下降，同组治疗前后比较差异有统计学意义（P<0.05），治疗后治疗组疼痛评分、僵硬评分、关节功能评分及总分均显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组软骨厚度均显著增加，滑膜厚度、IL-1β、MMP-3、COMP、PG均显著减少，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组软骨厚度显著高于对照组，滑膜厚度、IL-1β、MMP-3、COMP、PG显著低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 盐酸氨基葡萄糖胶囊联合复方骨肽注射液治疗膝骨关节炎具有较好的临床疗效，可有效缓解患者症状，减轻炎性损伤，具有一定的临床推广应用价值。

Objective To explore the clinical effect of Glucosamine Hydrochloride Capsules combined with Compound Ossotide Injection intreatment of knee osteoarthritis. Methods Patients (114 cases) with knee osteoarthritis in People's Hospital of Xiangxi Tujia and Miao Autonomous Prefecture from January 2016 to January 2018 were randomly divided into control (57 cases) and treatment (57 cases) groups. Patients in the control group were iv administered with Compound Ossotide Injection, 10 mL was fully diluted with 250 mL isobaric saline, once daily. Patients in the treatment group were po administered with Glucosamine Hydrochloride Capsules, 2 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the changes of WOMAC score, high frequency ultrasound parameters of knee joints, IL-1β, MMP-3, COMP, and PG in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group were 77.2% and 91.2%, and there were differences between two groups (P<0.05). After treatment, the pain score, stiffness score, joint function score and total score in two groups were significantly decreased, and there were differences in the same group (P<0.05).After treatment, the pain score, stiffness score, joint function score and total score in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). After treatment, cartilage thickness was increased significantly in both groups, but synovial thickness, IL-1β, MMP-3, COMP, and PG were significantly decreased, and there were differences in the same group (P<0.05). After treatment, cartilage thickness in the treatment group was higher than that in the control group, but synovial thickness, IL-1β, MMP-3, COMP, and PG were lower than those in the control group, and there were differences between two groups (P<0.05). Conclusion Glucosamine Hydrochloride Capsules combined with Compound Ossotide Injection has significant clinical effect in treatment of knee osteoarthritis, and can effectively alleviate symptoms, and reduce inflammatory injury, which has a certain clinical application value.