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[摘要]
目的 探讨抗骨增生胶囊联合戊酸雌二醇片治疗绝经后骨质疏松症的临床疗效。方法 选取2016年4月-2017年9月信阳市中心医院收治的绝经后骨质疏松症患者96例为研究对象,按照随机数字表法分为对照组和治疗组,每组各48例。对照组口服戊酸雌二醇片,1片/次,1次/d。治疗组在对照组治疗的基础上口服抗骨增生胶囊,5粒/次,3次/d。两组患者均连续治疗6个月。观察两组的临床疗效,比较两组的骨密度、骨代谢、VAS评分。结果 治疗后,对照组和治疗组的总有效率分别为77.08%、91.67%,两组比较差异有统计学意义(P<0.05)。治疗后,两组股骨颈、腰椎侧位、wards三角区、尺桡骨远端的骨密度显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组骨密度明显高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组骨钙素(BGP)水平显著升高,碱性磷酸酶(ALP)、Ⅰ型前胶原氨基末端肽(PINP)、Ⅰ型胶原羧基末端肽(CTX)水平显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组骨代谢指标明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组VAS评分明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组VAS评分明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论 抗骨增生胶囊联合戊酸雌二醇片治疗绝经后骨质疏松症具有较好的临床疗效,可改善骨代谢水平,提高骨密度,缓解疼痛,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the clinical effect of Kanggu Zengsheng Capsules combined with Estradiol Valerate Tablets in treatment of postmenopausal osteoporosis. Methods Patients (96 cases) with postmenopausal osteoporosis in Xinyang Central Hospital from April 2016 to September 2017 were randomly divided into control and treatment groups, and each group had 48 cases. Patients in the control group were po administered with Estradiol Valerate Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Kanggu Zengsheng Capsules on the basis of the control group, 5 grains/time, three times daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacies were evaluated, and bone mineral density, bone metabolism, VAS scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 77.08% and 91.67%, respectively, and there was difference between two groups (P<0.05). After treatment, the bone mineral density of femoral neck, lateral lumbar spine, wards triangle, and distal radioulnar in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the bone mineral density indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of BGP in two groups were significantly increased, but the levels of ALP, PINP, and CTX in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the bone metabolism indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, VAS scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And VAS scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Kanggu Zengsheng Capsules combined with Estradiol Valerate Tablets has clinical curative effect in treatment of postmenopausal osteoporosis, can improve the level of bone metabolism, increase bone mineral density, and relieve pain, which has a certain clinical application value.
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