[关键词]
[摘要]
目的 研究致康胶囊联合甲硝唑栓治疗老年性阴道炎的临床疗效。方法 选取2015年4月-2017年4月青海大学附属医院接收的120例老年性阴道炎患者作为研究对象,将所有患者随机分为对照组和治疗组,每组各60例。对照组在临睡前于阴道后穹窿处放置甲硝唑栓,1次/d,0.5 g/次。治疗组在对照组治疗的基础上口服致康胶囊,2粒/次,3次/d。两组患者均连续治疗10 d。观察两组的临床疗效,比较两组的临床症状改善情况、生活质量。结果 治疗后,对照组有效率为81.66%,治疗组的有效率为96.67%,治疗组显著高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者阴道灼热、外阴瘙痒、阴道壁红肿、白带增多发生率均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);并且治疗组患者的临床症状改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者躯体功能评分、心理功能评分、物质生活评分、社会功能评分和生活质量总分均明显提高,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组生活质量评分均明显提高,两组比较差异具有统计学意义(P<0.05)。结论 致康胶囊联合甲硝唑栓治疗老年性阴道炎具有较好的临床疗效,改善临床症状和生活质量,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Zhikang Capsules combined with Metronidazole Suppositories in treatment of senile vaginitis. Methods Patients (120 cases) with senile vaginitis in Affiliated Hospital of Qinghai University from April 2015 to April 2017 were randomly divided into control group and treatment group. Each group had 60 cases. Patients in the control group were placed Metronidazole Suppositories on the posterior fornix of the vagina before bedtime, 0.5 g/time, once daily. Patients in the treatment group were po Zhikang Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the improvement of clinical symptoms and quality of life were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 81.66% and 96.67% respectively, and there were differences between two groups (P<0.05). After treatment, the incidence rates of vaginal heat, vulva itch, vaginal wall redness, and leucorrhea in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the improvements of clinical symptoms in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the total scores of physical function, psychological function, material life score, social function and quality of life in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the qualities of life in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Zhikang Capsules combined with Metronidazole Suppositories has clinical curative effect in treatment of senile vaginitis, can improve the clinical symptoms and quality of life, which has a certain clinical application value.
[中图分类号]
[基金项目]