目的 探讨脉血康胶囊联合巴曲酶治疗突发性耳聋的临床效果。方法 选取天津市泰达医院2015年10月-2017年10月收治的突发性耳聋患者114例，随机分为对照组（57例）和治疗组（57例）。对照组静脉滴注巴曲酶注射液，首剂量为10 BU加入100 mL生理盐水，隔日1次，维持剂量为5 BU/次，每次给药时间>1 h。治疗组在对照组基础上口服脉血康胶囊，3粒/次，3次/d。两组均连续治疗10 d。观察两组患者临床疗效，同时比较治疗前后两组患者听力阈值、凝血-抗凝-纤溶系统指标、血液流变学指标和炎性因子水平。结果 治疗后，对照组和治疗组的临床总有效率分别为77.2%和91.2%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者0.5、1、2、4 kHz的听力阈值较治疗前均显著下降（P<0.01），且治疗后治疗组听力阈值明显低于对照组（P<0.01）。治疗后，两组血浆纤维蛋白原（FIB）水平和血清D-二聚体（D-D）水平均显著下降（P<0.01），血清抗凝血酶Ⅲ（ATⅢ）水平显著上升（P<0.01），且治疗后治疗组凝血-抗凝-纤溶系统指标优于对照组（P<0.01）。治疗后，两组患者红细胞沉降率（ESR）、血浆黏度（PV）值较治疗前明显降低（P<0.05），红细胞变形指数（EDI）值明显增加（P<0.05），且治疗后治疗组血液流变学指标明显优于对照组（P<0.05）。治疗后，两组患者白细胞介素（IL）-6、肿瘤坏死因子（TNF）-α和超敏C反应蛋白（hs-CRP）水平均显著下降（P<0.01），且治疗组上述炎性因子水平明显低于对照组（P<0.01）。结论 脉血康胶囊联合巴曲酶注射液治疗突发性耳聋可短期内消除患者耳周感觉异常、头晕等症状，有效调节凝血-抗凝-纤溶系统平衡，改善血液流变学状态，减轻炎性反应。

Objective To investigate the clinical effect of Maixuekang Capsules combined with batroxobin in treatment of sudden deafness. Methods Patients (114 cases) with sudden deafness in Tianiin TEDA Hospital from October 2015 to October 2017 were randomly divided into control (57 cases) and treatment (57 cases) groups. Patients in the control group were iv administered with Batroxobin Injection, the initial dosage was 10 BU, and were added into normal saline 100 mL, once every 2 d, the maintenance dose was 5 BU/time, and the administration time was more than 1 h. Patients in the treatment group were po administered with Maixuekang Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacy was evaluated, and the hearing thresholds, the coagulant, anticoagulant and fibrinolytic system indicators, the hemorheological indexes and the inflammatory cytokines in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 77.2% and 91.2% respectively, and there were differences between two groups (P<0.05). After treatment, the hearing thresholds of 0.5, 1, 2, and 4 kHz in two groups was significantly decreased (P<0.01), and the hearing thresholds in the treatment group after treatment was significantly lower than that in the control group (P<0.01). After treatment, the FIB and D-D levels in two groups were significantly decreased (P<0.01), but the ATⅢ levels were significantly increased (P<0.01), and the coagulant, anticoagulant and fibrinolytic system indicators in the treatment group after treatment were significantly better than those in the control group (P<0.01). After treatment, the ESR and PV in two groups were significantly decreased (P<0.05), but EDI were significantly increased (P<0.05), and the hemorheological indexes in the treatment group after treatment were significantly better than those in the control group (P<0.05). After treatment, the IL-6, TNF-α and hs-CRP levels in two groups was significantly decreased (P<0.01), and these the inflammatory cytokines levels in the treatment group after treatment were significantly lower than that in the control group (P<0.01). Conclusion Maixuekang Capsules combined with batroxobin in treatment of sudden deafness can shortly eliminate symptoms of abnormal auricular sensation,dizziness and so on, can effectively regulate the coagulation-anticoagulant-fibrinolytic system, improve the hemorheological, reduce the inflammatory reaction.