目的 探讨复方氯己定含漱液联合替硝唑治疗牙周病的临床疗效。方法 选取2017年5月-2017年11月在梧州市人民医院治疗的牙周病患者102例，随机分为对照组（51例）和治疗组（51例）。对照组口服替硝唑片，0.5 g/次，2次/d；治疗组在对照组基础上早晚含漱复方氯己定含漱液，15 mL/次。两组经过4周治疗。观察两组患者临床疗效，同时比较治疗前后两组患者牙周附着指数、牙菌斑指数、牙龈指数、牙齿松动度、炎症指标、OHIP-14和VAS评分。结果 治疗后，对照组临床有效率为80.39%，显著低于治疗组的96.08%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者牙周附着指数、牙菌斑指数、牙龈指数和牙齿松动度均显著降低（P<0.05），且治疗组降低程度明显优于对照组（P<0.05）。治疗后，两组血清白细胞介素-6（IL-6）、IL-Iβ、肿瘤坏死因子-α（TNF-α）、基质金属蛋白酶3（MMP-3）水平均显著降低（P<0.05），且治疗后治疗组IL-Iβ、IL-6、TNF-α和MMP-3水平明显低于对照组（P<0.05）。治疗后，两组OHIP-14和VAS评分均显著降低（P<0.05），且治疗后治疗组OHIP-14和VAS评分明显低于对照组（P<0.05）。结论 复方氯己定含漱液联合替硝唑治疗牙周病可有效降低机体炎症水平，改善患者口腔健康状况，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Compound Gargle Solution Chlorhexidine Giuconatie combined with tinidazole in treatment of periodontal diseases. Methods Patients (102 cases) with periodontal diseases in the People's Hospital of Wuzhou from May 2017 to November 2017 were randomly divided into control (51 cases) and treatment (51 cases) groups. Patients in the control group were po administered with Tinidazole Tablete, 0.5 g/time, twice daily. Patients in the treatment group were gargling administered with Compound Gargle Solution Chlorhexidine Giuconatie on the basis of the control group daily morning and evening, 4 grains/time. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the periodontal attachment index, dental plaque index, gingival index, tooth mobility, inflammatory markers, OHIP-14 and VAS in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.39%, which was significantly lower than 96.08% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the periodontal attachment index, dental plaque index, gingival index, tooth mobility in two groups were significantly decreased (P<0.05), and these indexes in the treatment group after treatment were significantly lower than those in the control group (P<0.05). After treatment, the IL-Iβ, IL-6, TNF-α and MMP-3 levels in two groups were significantly decreased (P<0.05), and these inflammatory markers levels in the treatment group after treatment were significantly lower than those in the control group (P<0.05). After treatment, the OHIP-14 and VAS in two groups were significantly decreased (P<0.05), and the OHIP-14 and VAS in the treatment group after treatment were significantly lower than that in the control group (P<0.05). Conclusion Compound Gargle Solution Chlorhexidine Giuconatie combined with tinidazole in treatment of periodontal diseases can effectively reduce the inflammation and improve oral health, which has a certain clinical application value.