目的 探讨甘珀酸钠片联合奥美拉唑肠溶胶囊治疗消化性溃疡的临床疗效。方法 选取2016年6月-2017年6月湖北医药学院附属人民医院收治的消化性溃疡患者102例作为研究对象，采取随机数字表法将所有患者分为对照组和治疗组，每组各51例。对照组口服奥美拉唑肠溶胶囊，40 mg/次，2次/d。治疗组在对照组治疗的基础上饭后口服甘珀酸钠片，第1周80 mg/次，3次/d，之后50 mg/次，3次/d。两组患者均连续治疗4周。观察两组的临床疗效，比较两组的溃疡愈合时间、临床症状消失时间。结果 治疗后，对照组、治疗组总有效率分别为84.31%、96.08%，两组总有效率比较差异有统计学意义（P<0.05）。治疗后，治疗组十二指肠溃疡、胃溃疡、复合溃疡愈合时间明显短于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组溃疡痛、烧心、反酸消失时间均明显短于对照组，两组比较差异具有统计学意义（P<0.05）。结论 甘珀酸钠片联合奥美拉唑肠溶胶囊治疗消化性溃疡临床疗效显著，能加快溃疡面愈合，改善临床症状，值得在临床推广应用。

Objective To investigate the effect of Carbenoxolone Sodium Tablets combined with Omeprazole Enteric-coated Capsules in treatment of pepti culcer. Methods Patients (102 cases) with peptic ulcer in Remin Hospital, Hubei University of Medicine from June 2016 to June 2017 were randomly divided into control and treatment groups, and each group had 51 cases. Patients in the control group were po administered with Omeprazole Enteric-coated Capsules after dinner, 40 mg/time, twice daily. Patients in the treatment group were po administered with Carbenoxolone Sodium Tablets on the basis of the control group, 80 mg/time, three times daily in the fist week, and then 50 mg/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the ulcer healing time and clinical symptoms disappeared times in two groups were compared. Results After treatment, the endoscopic efficacies in the control and treatment groups were84.31% and 96.08%, respectively, and there was difference between two groups (P<0.05). After treatment, healing times of duodenal ulcer, gastric ulcer and complex ulcer in the treatment group were significantly shorter than those in the control group, and there was difference between two groups (P<0.05). After treatment, the disappearance times of ulcerative pain, heart burning, and acid reacid were significantly shorter than those in the control group, and there was difference between two groups (P<0.05). Conclusion Carbenoxolone Sodium Tablets combined with Omeprazole Enteric-coated Capsules has clinical curative effect in treatment of pepti culcer, can accelerate the healing of ulcers, improve clinical symptoms, which has a certain clinical application value.