目的 研究蒲地蓝消炎口服液联合头孢呋辛酯颗粒治疗小儿急性上呼吸道感染的临床疗效。方法 选取2014年12月-2017年12月三台县人民医院收治的急性上呼吸道感染患儿100例作为研究对象，所有患儿随机分为对照组和治疗组，每组各50例。对照组口服头孢呋辛酯颗粒，30 mg/（kg·次），2次/d；治疗组在对照组治疗的基础上口服蒲地蓝消炎口服液，10 mL/次，3次/d。两组患儿均持续治疗10 d。观察两组的临床疗效，比较两组的临床症状消失时间、血清炎性因子水平。结果 治疗后，对照组和治疗组的总有效率分别为82.00%、94.00%，两组比较差异有统计学意义（P<0.05）。治疗后，治疗组退热时间、咽部充血消失时间、咽痛消失时间和止咳时间均显著短于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组血清炎性因子水平明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 蒲地蓝消炎口服液联合头孢呋辛酯颗粒治疗小儿急性上呼吸道感染具有较好的临床疗效，可改善患儿临床症状和炎性因子水平，安全性较好，具有一定的临床推广应用价值。

Objective To study the effect of Pudilan Xiaoyan Oral Liquid combined with Cefuroxime Axetil Granules in treatment of acute upper respiratory infection in children. Methods Children (100 cases) with acute upper respiratory infection in Santai People's Hospital from December 2014 to December 2017 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Cefuroxime Axetil Granules, 30 mg/(kg·time), twice daily. Patients in the treatment group were po administered with Pudilan Xiaoyan Oral Liquid on the basis of the control group, 10 mL/time, three times daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacies were evaluated, and the disappearance time of clinical symptoms and the serum levels of inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.00% and 94.00%, respectively, and there was difference between two groups (P<0.05). After treatment, the antipyretic time, the antitussive time, the disappearance time of pharynx hyperemia and sore throat in the treatment group were significantly shorter than those in the control group, and there was difference between two groups (P<0.05). After treatment, the levels of hs-CRP, IL-6, and TNF-α in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the serum levels of inflammatory factors in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Pudilan Xiaoyan Oral Liquid combined with Cefuroxime Axetil Granules has good clinical curative effect in treatment of acute upper respiratory infection in children, can improve the clinical symptoms and the levels of inflammatory factors, with good safety, which has a certain clinical application value.