目的 探讨小儿双金清热口服液联合磷酸奥司他韦胶囊治疗甲型流行性感冒（流感）的临床疗效。方法 选取2016年2月-2017年2月在延安市人民医院儿科和门诊进行治疗的甲型流感患者113例作为研究对象，在随机分组的原则下将患者随机分为对照组（56例）和治疗组（57例）。对照组患者口服磷酸奥司他韦胶囊，75 mg/次，2次/d；治疗组患者在对照组治疗的基础上口服小儿双金清热口服液，10 mL/次，3次/d。两组患者均连续治疗5 d。观察两组患者的临床疗效，同时比较治疗前后两组患者体温恢复时间、症状消失时间、病毒核酸阳性持续时间、细胞免疫指标和体液免疫指标水平。结果 治疗后，对照组、治疗组总有效率分别为83.93%、96.49%，两组总有效率比较差异具有统计学意义（P<0.05）。治疗后，治疗组体温恢复时间、症状消失时间和病毒核酸阳性持续时间均显著短于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血清CD8⁺水平显著降低，CD4⁺、IgA、IgM水平均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组细胞免疫和体液免疫指标明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 小儿双金清热口服液联合奥司他韦胶囊治疗甲型流感具有较好的临床疗效，改善临床症状，提高免疫力，具有一定的临床推广应用价值。

Objective To investigate the clinical effects of Xiao'er Shuangjin Qingre Oral Liquid combined with Oseltamivir Phosphate Capsules in treatment of influenza. Methods Patients (113 cases) with influenza in Yan'an People's Hospital from February 2016 to February 2017 were randomly divided into control (56 cases) and treatment (57 cases) groups. Patients in the control group were po administered with Oseltamivir Phosphate Capsules, 75 mg/time, twice daily. Patients in the treatment group were po administered with Xiao'er Shuangjin Qingre Oral Liquid on the basis of the control group, 10 mL/time, three times daily. Patients in two groups were treated for 5 days. After treatment, the clinical efficacy was evaluated, and the recovery time of body temperature, symptoms disappeared time, viral nucleic acid positive duration, and levels of cellular immune indexes and humoral immune indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 83.93% and 96.49%, respectively, and there were differences between two groups (P<0.05). After treatment, the recovery time of body temperature, symptoms disappeared time and duration of virus nucleic acid positive in the treatment group were significantly shorter than those in the control groups, and there was difference between two groups (P<0.05). After treatment, the CD8⁺ levels in two groups were significantly decreased, but CD4⁺, IgA, and IgM levels were significantly increased, and the difference was statistically significant in the same group (P<0.05). And levels of cellular immune indexes and humoral immune indexes in the treatment group after treatment were significantly better than those in the control group (P<0.05). Conclusion Xiao'er Shuangjin Qingre Oral Liquid combined with Oseltamivir Phosphate Capsules has obvious curative effect in treatment of influenza, can improve the clinical symptoms and the immunity, which has a certain clinical application value.