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[摘要]
目的 探讨安脑丸联合阿立哌唑治疗精神分裂症的临床疗效。方法 选取2015年4月-2017年4月在河南省洛阳荣康医院进行诊治的精神分裂症患者92例,随机分为对照组(46例)和治疗组(46例)。对照组口服阿立哌唑片,第1周剂量5 mg/d,第2周10 mg/d,之后根据疗效和耐受情况增至15 mg/d维持治疗,1次/d;治疗组在对照组的基础上口服安脑丸,2丸/次,2次/d。两组均治疗6周。观察两组患者临床疗效,比较治疗前后两组患者PANSS、GQOLI-74和PSP评分以及血清学指标。结果 治疗后,对照组和治疗组的临床有效率分别为80.43%和95.65%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者PANSS评分显著降低,GQOLI-74和PSP评分显著升高,同组比较差异具有统计学意义(P<0.05),且治疗组上述评分明显优于对照组(P<0.05)。治疗后,两组患者神经元特异性烯醇化酶(NSE)、S100β蛋白、髓鞘碱性蛋白(MBP)水平均显著降低,胶质源性神经营养因子(GDNF)水平显著升高,同组比较差异具有统计学意义(P<0.05),且治疗组上述血清学指标明显优于对照组(P<0.05)。结论 安脑丸联合阿立哌唑治疗精神分裂症可有效改善患者阳性和阴性症状,改善机体NSE、S100B蛋白、MBP、GDNF水平,具有一定的临床推广应用价值。
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[Abstract]
Objective To explore the clinical efficacy of Annao Pills combined with aripiprazole in treatment of schizophrenia. Methods Patients (92 cases) with schizophrenia in Henan Province Had Luoyang Hospital from April 2015 to April 2017 were randomly divided into control (46 cases) and treatment (46 cases) groups. Patients in the control group were po administered with Aripiprazole Tablets, 5 mg/d for the 1st week, 10 mg/d for the 2nd week, then increased to 15 mg/d for maintaining treatment according to the efficacy and tolerance, once daily. Patients in the treatment group were po administered with Annao Pills on the basis of the control group, 2 pills/time, twice daily. Patients in two groups were treated for 6 weeks. After treatment, the clinical efficacy was evaluated, and the PANSS, GQOLI-74, and PSP scores, the serological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 80.43% and 95.65%, respectively, and there were differences between two groups (P<0.05). After treatment, the PANSS scores in two groups were significantly decreased, but GQOLI-74 and PSP scores were significantly increased, and the difference was statistically significant in the same group (P<0.05), and these scores in the treatment group after treatment were significantly better than those in the control group (P<0.05). After treatment, the NSE, S100β and MBP levels in two groups were significantly decreased, but GDNF levels were significantly increased, and the difference was statistically significant in the same group (P<0.05), and the serological indexes in the treatment group after treatment were significantly better than those in the control group (P<0.05). Conclusion Annao Pills combined with aripiprazole in treatment of schizophrenia can effectively improve the positive and negative symptoms, and improve the NSE,S100β protein, MBP and GDNF levels, which has a certain clinical application value.
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