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[摘要]
目的 探讨苦碟子注射液联合替格瑞洛片治疗冠心病心绞痛的疗效。方法 选取2016年4月-2017年11月武汉市汉口医院收治的冠心病心绞痛患者76例为研究对象,按照随机数字表法分为对照组和治疗组,每组各38例。对照组口服替格瑞洛片,90 mg/次,首周2次/d,而后1次/d。治疗组在对照组治疗的基础上静脉滴注苦碟子注射液,30 mL加入到生理盐水250 mL中,1次/d。两组患者均连续治疗4周。观察两组的临床疗效和心电图疗效,比较两组的血液流变学、心绞痛发作频率和持续时间。结果 治疗后,对照组和治疗组的总有效率分别为78.95%、94.74%,两组比较差异有统计学意义(P<0.05)。治疗后,对照组和治疗组的心电图疗效总有效率分别为60.53%、81.58%,两组比较差异有统计学意义(P<0.05)。治疗后,两组血浆比黏度(PSV)、全血黏度(WBV)、血细胞比容(HCT)、纤维蛋白原(FIB)显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组血液流变学指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组心绞痛发作频率、心绞痛持续时间明显下降,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论 苦碟子注射液联合替格瑞洛片治疗冠心病心绞痛具有较好的临床疗效,可改善血液流变学,降低心绞痛发作频率和持续时间,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the effect of Kudiezi Injection combined with Ticagrelor Tablets in treatment of angina pectoris of coronary heart disease. Methods Patients (76 cases) with angina pectoris of coronary heart disease in Wuhan Hankou Hospital from April 2016 to November 2017 were randomly divided into control and treatment groups, and each group had 38 cases. Patients in the control group were po administered with Ticagrelor Tablets, 90 mg/time, twice daily in the first week, then once daily. Patients in the treatment group were iv administered with Kudiezi Injection on the basis of the control group, 30 mL added into normal saline 250 mL, once daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies and electrocardiogram efficacies were evaluated, hemorheology, the frequency and duration of angina pectoris in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 78.95% and 94.74%, respectively, and there was difference between two groups (P<0.05). After treatment, the electrocardiogram efficacies in the control and treatment groups were 60.53% and 81.58%, respectively, and there was difference between two groups (P<0.05). After treatment, PSV, WBV, HCT, and FIB in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the hemorheology indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the frequency and duration of angina pectoris in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Kudiezi Injection combined with Ticagrelor Tablets has clinical curative effect in treatment of angina pectoris of coronary heart disease, can improve hemorheology, decrease the frequency and duration of angina pectoris, which has a certain clinical application value.
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