目的 分析华中科技大学同济医学院附属协和医院肿瘤中心抗菌药物的使用情况，为肿瘤患者使用抗菌药物的质量控制提供参考依据。方法 对华中科技大学同济医学院附属协和医院肿瘤中心2015年1月-2017年12月抗菌药物的用药品种、销售金额、用药频度（DDDs）、日均药费（DDC）和排序比（B/A）等进行统计分析。结果 2015-2017年抗菌药物的销售金额占总药品金额的比例分别为5.23%、4.67%、4.33%；头孢菌素类的销售金额和DDDs排名连续3年位居第1位，碳青霉烯类、糖肽类、唑酮类的销售金额、DDDs较前两年有明显的增长；青霉素类、头孢菌素类、喹诺酮类及和抗真菌药品B/A均为1.00，氨基苷类、硝咪唑类的B/A均大于1.00，β-内酰胺类复方制剂、碳青霉烯类、糖肽类、唑酮类的B/A均小于1.00；DDDs排名前15名的抗菌药物3年来每种药物的DDC都在逐年降低。结论 华中科技大学同济医学院附属协和医院肿瘤中心抗菌药物的使用日趋合理，但患者的经济负担较重，应进一步加强管理。

Objective To investigate the use of antibiotics in Tumor Center of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, and to provide reference for the quality control of antibiotics used in cancer patients. Methods The drug category, consumption sums, defined daily dose system (DDDs), average daily cost (DDC) and B/A values of antibiotics from January 2015 to December 2017 in Tumor Center of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology were analyzed statistically. Results The consumption amount of antibacterial drugs accounted for 5.23%, 4.67%, and 4.33% from 2015 to 2017. Consumption sums and DDDs of cephalosporins ranked the first in three consecutive years. Consumption sums and DDDs of the antibiotics, including carbapenenes, glycopeptides and oxazolone, were significantly increased compared with those of the previous two years. B/A of penicillin, cephalosporin, quinolone, and antifungal drugs were all 1.00. B/A of aminoglycoside and nitroimidazoles were above 1.00 in 3 years. B/A of glycopeptide, oxazolone, carbapenem, β-lactamase antibiotics were less than 1.00. DDC of antibacterial drugs with top 15 DDDs had been decreasing year by year in the past 3 years. Conclusion The use of antimicrobial agents in Tumor Center of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology is becoming more and more reasonable. But the patients' financial burden is still heavy, therefore, further management should be strengthened.