目的 探究白芍总苷胶囊联合他克莫司胶囊治疗系统性红斑狼疮的临床疗效。方法 选取2014年10月-2016年6月什邡市人民医院收治的系统性红斑狼疮患者90例为研究对象，将患者按随机数字表法分为对照组和治疗组，每组各45例。对照组口服他克莫司胶囊，起始剂量0.05 mg/（kg·d），2次/d，维持血药浓度5~10 μg/L。治疗组在对照组治疗的基础上口服白芍总苷胶囊，2粒/次，2次/d。两组患者均连续治疗6个月。观察两组的临床疗效，比较两组的系统性红斑狼疮疾病活动指数（SLEDAI）评分、糖皮质激素日用量、血清因子和复发率。结果 治疗后，对照组和治疗组的总有效率分别为75.56%、91.11%，两组比较差异有统计学意义（P<0.05）。治疗后，两组SLEDAI评分和糖皮质激素日用量均明显下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组疫球蛋白A（IgA）、IgG、IgM水平均明显下降，补体C3、C4水平均明显上升，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些血清因子水平均明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组抗双链DNA抗体（A-dsDNA）、抗Sm抗体（ASm）、抗核抗体（ANA）及抗组蛋白抗体（AHA）转阴率均明显高于对照组，两组比较差异具有统计学意义（P<0.05）。对照组和治疗组复发率分别为为31.11%、13.33%，两组比较差异具有统计学意义（P<0.05）。结论 白芍总苷胶囊联合他克莫司胶囊治疗系统性红斑狼疮具有较好的临床疗效，可改善患者免疫功能，减少糖皮质用量，降低复发率，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Total Glucosides of Paeony Capsules combined with Tacrolimus Capsules in treatment of systemic lupus erythematosus. Methods Patients (90 cases) with systemic lupus erythematosus in Shifang People's Hospital from October 2014 to June 2016 were randomly divided into control and treatment groups, and each group had 45 cases. Patients in the control group were po administered with Tacrolimus Capsules, starting dosage 0.05 mg/(kg·d), twice daily, the maintenance of blood drug concentration was 5-10 μg/L. Patients in the treatment group were po administered with Total Glucosides of Paeony Capsules on the basis of the control group, 2 grains/time, twice daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacies were evaluated, and SLEDAI scores, glucocorticoid daily dosage, serum factors, and recurrence rate in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 75.56% and 91.11%, respectively, and there was difference between two groups (P<0.05). After treatment, SLEDAI scores and glucocorticoid daily dosage in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of IgA, IgG, and IgM in two groups were significantly decreased, but the levels of C3 and C4 in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the serum factors levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the negative rate of A-dsDNA, ASm, ANA, and AHA in the treatment group were significantly higher than those in the control group, and there was difference between two groups (P<0.05). The recurrence rates in the control and treatment groups were 31.11% and 13.33%, respectively, and there was difference between two groups (P<0.05). Conclusion Total Glucosides of Paeony Capsules combined with Tacrolimus Capsules has clinical curative effect in treatment of systemic lupus erythematosus, can improve immune function, decrease glucocorticoid dosage and reduce recurrence rate, which has a certain clinical application value.