目的 探讨舒肝解郁胶囊联合盐酸阿米替林片治疗老年抑郁症的临床疗效。方法 选取2015年6月-2017年6月绵阳市第三人民医院收治的老年抑郁症患者120例作为研究对象，所有患者随机分为对照组和治疗组，每组各60例。对照组口服盐酸阿米替林片，4片/次，2次/d。治疗组在对照组治疗基础上口服舒肝解郁胶囊，2粒/次，2次/d。两组患者均持续治疗28 d。观察两组的临床疗效，比较两组的汉密尔顿抑郁量表（HAMD）评分和汉密尔顿焦虑量表（HAMA）评分。结果 治疗后，对照组和治疗组的总有效率分别为81.67%、96.67%，两组比较差异有统计学意义（P<0.05）。治疗后，两组HAMA评分和HAMD评分均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组HAMA评分和HAMD评分均明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 舒肝解郁胶囊联合盐酸阿米替林片治疗老年抑郁症具有较好的临床疗效，可改善临床症状，安全性较好，具有一定的临床推广应用价值。

Objective To investigate the clinical effects of Shugan Jieyu Capsules combined with Amitriptyline Hydrochloride Tablets in treatment of senile depression. Methods Patients (120 cases) with senile depression in the Third People's Hospital of Mianyang from June 2015 to June 2017 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Amitriptyline Hydrochloride Tablets, 4 tablets/time, twice daily. Patients in the treatment group were po administered with Shugan Jieyu Capsules on the basis of the control group, 2 grains/time, twice daily. Patients in two groups were treated for 28 d. After treatment, the clinical efficacies were evaluated, and HAMD scores and HAMA scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.67% and 96.67%, respectively, and there was difference between two groups (P<0.05). After treatment, HAMD scores and HAMA scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And HAMD scores and HAMA scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Shugan Jieyu Capsules combined with Amitriptyline Hydrochloride Tablets has clinical curative effect in treatment of senile depression, can improve clinical symptoms, with good safety, which has a certain clinical application value.