目的 探讨如意金黄散联合伐昔洛韦治疗带状疱疹的临床疗效。方法 选取2017年5月-2017年11月在无锡市第三人民医院进行治疗的带状疱疹患者86例，随机分为对照组（43例）和治疗组（43例）。对照组口服盐酸伐昔洛韦片，0.3 g/次，2次/d。治疗组在对照组基础上于患处外敷如意金黄散，取适量用醋调成糊状。两组患者均治疗10 d。观察两组患者的临床疗效，同时比较治疗前后两组患者临床症状改善时间、血清学指标及数字疼痛评分量表（NRS）、皮肤病生活质量指数评分（DLQI）和匹兹堡睡眠质量评分（PSQI）。结果 治疗后，对照组临床有效率为81.40%，显著低于治疗组的97.67%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组疼痛完全消失时间、皮损停止进展时间、结痂时间均明显短于对照组（P<0.05）。治疗后，两组血清IL-4、IL-6、IL-1β水平显著降低，IL-2和γ-干扰素（IFN-γ）水平显著升高，同组治疗前后比较差异具有统计学意义（P<0.05），且治疗后治疗组血清学指标明显优于对照组（P<0.05）。治疗后，两组患者NRS、DLQI、PSQI评分显著降低（P<0.05）；且治疗后治疗组NRS、DLQI、PSQI评分明显低于对照组（P<0.05）。结论 如意金黄散联合伐昔洛韦治疗带状疱疹可有效改善患者临床症状，抑制机体炎症反应，具有一定的临床推广应用价值。

Objective To evaluate the clinical efficacy of Ruyi Jinhuang Powder combined with valaciclovir in treatment of herpes zoster. Methods Patients (86 cases) with herpes zoster in Wuxi Third People's Hospital from May 2017 to November 2017 were randomly divided into control group (43 cases) and treatment group (43 cases). Patients in the control group were po administered with Valaciclovir Hydrochloride Tablets, 0.3 g/time, twice daily. Patients in the treatment group were external administered with Ruyi Jinhuang Powder on the basis of control group, and appropriate amount was made to paste with vinegar. Patients in two groups were treated for 10 d. After treatment, the clinical efficacy was evaluated, and the improvement time of clinical symptoms, the serological indexes, the NRS, DLQI and PSQI scores in two groups before and after treatment was compared. Results After treatment, the clinical efficacy in the control group was 81.40%, which was significantly lower than 97.67% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the pain disappeared time, time to stop the progress of skin lesions, and escharosis time in the treatment group were significantly shorter than those in the control group (P<0.05). After treatment, the IL-4, IL-6, and IL-1β levels in two groups were significantly decreased, but IL-2 and IFN-γ levels were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the serological indexes in the treatment group after treatment were significantly better than those in the control group (P<0.05). After treatment, the NRS, DLQI and PSQI scores in two groups were significantly decreased (P<0.05), and these scores in the treatment group after treatment were significantly lower than those in the control group (P<0.05). Conclusion Ruyi Jinhuang Powder combined with valaciclovir in treatment of herpes zoster can effectively improve the clinical symptoms, and suppress the inflammatory reaction, which has a certain clinical application value.