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[摘要]
目的 探讨至灵胶囊联合替米沙坦治疗早期糖尿病肾病的临床疗效。方法 选取2013年1月-2016年1月天津市第一中心医院收治的98例糖尿病肾病患者,随机分为对照组(50例)和治疗组(48例)。对照组患者口服替米沙坦片,1片/次,1次/d。治疗组在对照组治疗基础上口服至灵胶囊,2粒/次,3次/d。两组均连续治疗12周。观察两组的临床疗效,比较两组患者治疗前后24 h尿蛋白定量、血肌酐(Scr)、尿酸(UA)、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)、白介素-6(IL-6)、内皮素(ET)、一氧化氮(NO)的变化情况。结果 治疗后,对照组和治疗组的总有效率分别为80.00%、93.75%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组24 h尿蛋白定量、Scr、UA、TNF-α、IL-6、CRP、ET均较治疗前明显降低,NO较治疗前明显升高,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组24 h尿蛋白定量、Scr、UA、TNF-α、IL-6、CRP、ET水平显著低于对照组,NO较治疗前明显升高,两组比较差异有统计学意义(P<0.05)。结论 至灵胶囊联合替米沙坦治疗糖尿病肾病具有较好的临床疗效,可有效降低炎症因子水平,改善血管内皮功能,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the efficacy of Zhiling Capsule combined with telmisartan in treatment of early diabetic nephropathy. Methods Patients (98 cases) with early diabetic nephropathy in Tianjin First Center Hospital from January 2013 to January 2016 were randomly divided into control (50 cases) and treatment (48 cases) groups. Patients in the control group were po administered with Telmisartan Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Zhiling Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacy was evaluated, and the changes of 24 h urinary protein quantification, Scr, UA, TNF-α, CRP, IL-6, ET, and NO in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group were 80.00% and 93.75%, and there were differences between two groups (P<0.05). After treatment, 24 h urinary protein quantification, Scr, UA, TNF-α, IL-6, CRP, and ET in two groups were significantly decreased, but NO was significantly increased, and there were differences in the same group (P<0.05). After treatment, 24 h urinary protein quantification, Scr, UA, TNF-α, IL-6, CRP, and ET in the treatment group were lower than those in the control group, but NO was higher than that in the control group, and there were differences between two groups (P<0.05). Conclusion Zhiling Capsule combined with telmisartan has significant clinical effect in treatment of early diabetic nephropathy, and can effectively reduce the level of inflammatory factors and improve vascular endothelial function, which has a certain clinical application value.
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