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[摘要]
目的 观察津力达颗粒联合格列吡嗪治疗2型糖尿病的临床疗效。方法 选取2016年6月-2017年6月四川省科学城医院收治的2型糖尿病患者120例,随机分为对照组和治疗组,每组各60例。对照组口服格列吡嗪缓释片,5 mg/次,1次/d;治疗组在对照组治疗基础上口服津力达颗粒,1袋/次,3次/d。两组均连续治疗8周。观察两组的临床疗效,比较两组治疗前后空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、β细胞胰岛素分泌功能(HOMA-β)、胰岛素敏感指数(HOMA-IS)、高敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)的变化情况。结果 治疗后,对照组和治疗组的总有效率分别为71.67%、88.33%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组FPG、2 hPG、糖化血红蛋白、TG、TC、LDL-C、hs-CRP、IL-6水平均较治疗前显著降低,但FINS、HOMA-β、HOMA-IS显著升高,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组FPG、2 hPG、糖化血红蛋白、TG、TC、LDL-C、hs-CRP、IL-6水平显著低于对照组,FINS、HOMA-β、HOMA-IS显著高于对照组,两组比较差异具有统计学意义(P<0.05)。结论 津力达颗粒联合格列吡嗪治疗2型糖尿病具有较好的临床疗效,可明显降低患者血糖、血脂水平,改善患者炎症状态,具有一定的临床推广应用价值。
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[Abstract]
Objective To observe the clinical curative effect of Jinlida Granules combined with glipizide in treatment of type 2 diabetes. Method Patients (120 cases) with type 2 diabetes in Sichuan Science City Hospital from June 2016 to June 2017 were randomly divided into control (60 cases) and treatment (60 cases) groups. Patients in the control group were po administered with Glipizide Sustained Release Tablets, 5 mg/time, once daily. Patients in the treatment group were po administered with Jinlida Granules, 1 bag/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the changes of FPG, 2 hPG, HbA1c, TG, TC, LDL-C, HOMA-β, HOMA-IS, hs-CRP, and IL-6 in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group were 71.67% and 88.33%, and there were differences between two groups (P<0.05). After treatment, FPG, 2 hPG, HbA1c, TG, TC, LDL-C, hs-CRP, and IL-6 in the two groups were significantly decreased, but FINS, HOMA-β, and HOMA-IS were significantly increased, and there were differences in the same group (P<0.05). After treatment, FPG, 2 hPG, HbA1c, TG, TC, LDL-C, hs-CRP, and IL-6 in the treatment group were lower than those in the control group, but FINS, HOMA-β, and HOMA-IS were significantly higher than those in the control group, and there were differences between two groups (P<0.05). Conclusion Jinlida Granules combined with glipizide has significant clinical effect in treatment of type 2 diabetes, and can significantly reduce blood glucose and lipid levels, and also can improve inflammatory state, which has a certain clinical application value.
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