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[摘要]
目的 探讨骨愈灵片联合鲑降钙素注射液治疗老年骨质疏松症胸腰椎压缩性骨折的临床疗效。方法 选取2016年7月-2017年7月在郑州市骨科医院治疗的骨质疏松性胸腰椎压缩骨折患者76例为研究对象,采用计算机随机分组法将患者分为对照组和治疗组,每组各38例。对照组肌肉注射鲑鱼降钙素注射液,第1天50 IU/次,之后100 IU/次,1次/d,连续治疗20 d,而后停药20 d,之后重复上述方式。治疗组在对照组治疗基础上口服骨愈灵片,2 g/次,3次/d。两组均连续治疗4个月。观察两组的临床疗效,比较两组的骨密度(BMD)、血清骨转换指标水平、视觉模拟评分法(VAS)评分和Oswestry功能障碍指数问卷表(ODI)评分。结果 治疗后,对照组和治疗组的总有效率分别为81.58%、97.37%,两组比较差异有统计学意义(P<0.05)。治疗后,两组血清β-胶原降解产物(β-CTX)、I型前胶原氨基端前肽(PINP)、骨钙素(BGP)、骨碱性磷酸酶(BALP)水平显著降低,BMD、25羟维生素D[25-(OH) D]水平显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组VAS评分和ODI评分均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些评分明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论 骨愈灵片联合鲑降钙素注射液治疗老年骨质疏松症胸腰椎压缩性骨折具有较好的临床疗效,可缓解疼痛,加快骨折愈合,增加骨密度,调节血清骨转换指标,具有一定的临床推广应用价值。
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[Abstract]
Objective To explore the clinical effect of Guyuling Tablets combined with Salmon Calcitonin Injection in treatment of senile osteoporosis complicated with compression fracture of thoracolumbar vertebrae. Methods Elderly patients (76 cases) with osteoporosis complicated with compression fracture of thoracolumbar vertebrae in Zhengzhou Orthopedics Hospital from July 2016 to July 2017 were divided into control and treatment groups according to computer random grouping method, and each group had 38 cases. Patients in the control group were im administered with Salmon Calcitonin Injection, first day 50 IU/time, afterwards 100 IU/time, once daily, treated for 20 d, then stopped for 20 d, and repeated the above method. Patients in the treatment group were po administered with Guyuling Tablets on the basis of the control group, 2 g/time, three times daily. Patients in two groups were treated for 4 months. After treatment, the clinical efficacies were evaluated, and BMD, serum bone conversion indexes, VAS scores, and ODI scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.58% and 97.37%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of β-CTX, PINP, BGP, and BALP in two groups were significantly decreased, but the levels of BMD and 25-(OH)D in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, VAS scores and ODI scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Guyuling Tablets combined with Salmon Calcitonin Injection has clinical curative effect in treatment of senile osteoporosis complicated with compression fracture of thoracolumbar vertebrae, can relieve patient's pain, accelerate patient's fracture healing, increase bone mineral density, and regulate serum bone turnover indexes, which has a certain clinical application value.
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