目的 探讨左归丸联合鲑鱼降钙素治疗老年骨质疏松症的临床效果。方法 选取2016年1月-2017年6月安阳市第六人民医院收治的126例老年骨质疏松症患者，随机分为对照组和治疗组，每组各63例。对照组肌肉注射注射用鲑鱼降钙素，50 U/次，1次/d。治疗组在对照组治疗基础上口服左归丸，9 g/次，2次/d。两组均连续治疗3个月。观察两组的临床疗效，比较两组治疗前后两组患者症状积分、不同部位骨密度（BMD）、肿瘤坏死因子（TNF）-α、骨碱性磷酸酶（BALP）、酸性磷酸酶（TRACP）、尿脱氧吡啶啉排泄率（D-Pyr/Cr）的变化情况。结果 治疗后，对照组和治疗组的总有效率分别为80.95%、93.65%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组各项症状积分、总分、TNF-α、BALP、TRACP、尿中D-Pyr/Cr值均显著降低，跟骨、Ward三角区、全髋骨、腰椎L_2-4的BMD值较治疗前均显著增高，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组各项症状积分、总分、TNF-α、BALP、TRACP、尿中D-Pyr/Cr值均显著低于对照组，跟骨、Ward三角区、全髋骨、腰椎L_2-4的BMD值较治疗前均显著增高，高于对照组，两组比较差异具有统计学意义（P<0.05）。结论 左归丸联合鲑鱼降钙素治疗老年骨质疏松症具有较好的临床疗效，可明显减轻患者的临床症状，增加骨密度，调控骨代谢平衡，具有一定的临床推广应用价值。

Objective To investigate the clinical effects of Zuogui Pills combined with salmon calcitonin in treatment of senile osteoporosis. Methods Patients (126 cases) with senile osteoporosis in Anyang People's Hospital No.6 from January 2016 to June 2017 were randomly divided into control (63 cases) and treatment (63 cases) groups. Patients in the control group were im administered with Salcatonin for injection, 50 U/time, once daily. Patients in the treatment group were po administered with Zuogui Pills on the basis of the control group, 9 g/time, twice dialy. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the changes of symptoms integral, BMD of different parts, TNF-α, BALP, TRACP, and D-Pyr/Cr of urine in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group were 80.95% and 93.65%, and there were differences between two groups (P<0.05). After treatment, symptoms integrals, total integral, TNF-α, BALP, TRACP, and D-Pyr/Cr of urine in two groups were significantly decreased, but BMD of calcaneal, ward triangle, total hip, and lumbar 2-4 were significantly increased, and there were differences in the same group (P<0.05). After treatment, symptoms integrals, total integral, TNF-α, BALP, TRACP, and D-Pyr/Cr of urine in the treatment group were lower than those in the control group, but BMD of calcaneal, ward triangle, total hip, and lumbar 2-4 were higher than those in the control group, and there were differences between two groups (P<0.05). Conclusion Zuogui Pills combined with salmon calcitonin has significant clinical effect in treatment of senile osteoporosis, and can significantly reduce clinical symptoms, and can increase bone density and regulate bone metabolism balance, which has a certain clinical application value.