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[摘要]
目的 探讨康复新液联合琥珀酸索利那新片治疗前列腺电切术后膀胱痉挛的临床疗效。方法 选取2017年1月-2018年1月河北省沧州中西医结合医院收治的前列腺电切术术后膀胱痉挛患者100例为研究对象,根据随机区组设计法将患者分为对照组和治疗组,每组各50例。对照组于术后当天口服琥珀酸索利那新片,5 mg/次,1次/d,尿管拔除后用生理盐水持续冲洗膀胱。治疗组在对照组治疗的基础上口服康复新液,10 mL/次,3次/d,尿管拔除后用生理盐水与康复新液以1:10比例持续冲洗膀胱。两组患者均在拔除尿管后3 d停药。观察两组的临床疗效,比较两组的膀胱功能改善情况、膀胱功能评分、临床治疗指标。结果 治疗后,对照组和治疗组的总有效率分别为82.0%、96.0%,两组比较差异有统计学意义(P<0.05)。与术后1 d比较,两组术后2、3 d膀胱痉挛次数、持续时间、尿频次数、尿急次数均显著下降,且治疗组术后1、2、3 d痉挛次数、持续时间、尿频次数、尿急次数均显著低于同期对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组VAS疼痛评分、OABSS评分、PPBC评分均显著下降,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组膀胱功能评分明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组膀胱冲洗、冲洗液转清、留置导尿管时间均显著短于对照组,两组比较差异具有统计学意义(P<0.05)。结论 康复新液联合琥珀酸索利那新片治疗前列腺电切术后膀胱痉挛具有较好的临床疗效,可改善临床症状,促进膀胱功能恢复,安全性较好,具有一定的临床推广应用价值。
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[Abstract]
Objective To investigate the effect of Kangfuxin Liquid combined with Solifenacin Succinate Tablets in treatment of bladder spasm after prostatic electrocision. Methods Patients (100 cases) with bladder spasm after prostatic electrocision in Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from January 2017 to January 2018 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Solifenacin Succinate Tablets after operation, 5 mg/time, once daily, after removal of catheter, continuous irrigation of the bladder with normal saline. Patients in the treatment group were po administered with Kangfuxin Liquid on the basis of the control group, 10 mL/time, three times daily, after removal of catheter, continuous irrigation of the bladder with normal saline and Kangfuxin Liquid (1:10). Patients in two groups were stopped taking medicine after removal of catheter for 3 d. After treatment, the clinical efficacies were evaluated, and the improvement of bladder function, the scores of bladder function, and the clinical treatment indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.0% and 96.0%, respectively, and there was difference between two groups (P<0.05). Comparison with 1 d after operation, frequency of spasm, duration of spasm, frequency of urination and number of urgency in two groups were significantly decreased at 2 and 3 d after operation, and the difference was statistically significant in the same group (P<0.05). And at 1, 2, and 3 d after operation, the observational indexes in the treatment group were significantly lower than those in the control group at the same time, with significant difference between two groups (P<0.05). After treatment, the scores of VAS, OABSS, and PPBC in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the time of bladder irrigation, rinse fluid, and indwelling catheter in the treatment group were significantly shorter than those in the control group, and there was difference between two groups (P<0.05). Conclusion Kangfuxin Liquid combined with Solifenacin Succinate Tablets has clinical curative effect in treatment of bladder spasm after prostatic electrocision, can improve clinical symptoms, and promot bladder function recovery, with good safety, which has a certain clinical application value.
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