目的 探讨滋肾育胎丸联合烯丙雌醇片治疗先兆流产的有效性与安全性。方法 选取郑州大学附属洛阳中心医院2015年5月-2017年5月收治的先兆流产患者141例，随机分成治疗组（71例）和对照组（70例）。对照组患者口服烯丙雌醇片，2片/次，1次/d；治疗组患者在对照组基础上口服滋肾育胎丸，5 g/次，3次/d。两组患者均经连续治疗7 d。评价两组患者保胎成功率，同时比较治疗前后两组患者止血时间、腰腹疼痛缓解时间、阴道流血量、孕酮、子宫动脉血流阻力指数（RI）和搏动指数（PI）水平及不良反应情况。结果 治疗后，对照组保胎成功率为75.71%，显著低于治疗组的90.14%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组患者止血时间和腰腹疼痛缓解时间显著短于对照组，治疗组阴道流血量显著小于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者孕酮水平显著升高，RI和PI水平显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）。且治疗后治疗组患者孕酮、RI和PI水平明显优于对照组（P<0.05）。治疗期间，对照组患者不良反应为15.71%，显著高于治疗组的4.23%，两组比较差异具有统计学意义（P<0.05）。结论 滋肾育胎丸联合烯丙雌醇片治疗先兆流产保胎率高，不良反应发生率低，具有一定的临床推广应用价值。

Objective To explore the effectiveness and safety of Zishen Yutai Pills combined with allylestrenol in treatment of threatened abortion. Methods Patients (141 cases) with threatened abortion in Luoyang Central Hospital Affiliated to Zhengzhou University from May 2015 to May 2017 were randomly divided into control (70 cases) and treatment (71 cases) groups. Patients in the control group were po administered with Allylestrenol Tablets, 2 tablets/time, once daily. Patients in the treatment group were po administered with Zishen Yutai Pills on the basis of the control group, 5 g/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the success rate of tocolysis was evaluated, the hemostasis time, remission time of lumbar abdominal pain, vaginal bleeding, progesterone, RI and PI levels, and the adverse reactions in two groups before and after treatment were compared. Results After treatment, the success rate of tocolysis in the control group was 75.71%, which was significantly lower than 90.14% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the hemostasis time and remission time of lumbar abdominal pain in the treatment group was significantly shorter than that in the control group, and the vaginal bleeding volume was significantly smaller than that in the control group, with significant difference between two groups (P<0.05). After treatment, the progesterone level in two groups was significantly increased, but RI and PI level was significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the progesterone, RI, and PI level in the treatment group after treatment were significantly better than those in the control group (P<0.05). During the treatment, the adverse reactions rate in the control group was 15.71%, which was significantly higher than 4.23% in the treatment group, with significant difference between two groups (P<0.05). Conclusion Zishen Yutai Pills combined with allylestrenol has higher tocolysis rate in treatment of threatened abortion with lower adverse reactions incidence, which has a certain clinical application value.