目的 探讨红核妇洁洗液联合克霉唑阴道片治疗霉菌性阴道炎的临床疗效。方法 选取2015年12月-2016年12月在河南省省立医院进行治疗的霉菌性阴道炎患者92例，随机将患者分为对照组（46例）和治疗组（46例）。对照组阴道深部放入克霉唑阴道片，1片/d；治疗组在对照组基础上阴道冲洗和外阴擦洗红核妇洁洗液，与清水按1：10稀释，2次/d。两组均经过10 d治疗。评价两组患者临床疗效，同时比较治疗前后两组患者临床症状、GQOLI-74量表评分、血清炎症指标和霉菌检出率。结果 治疗后，对照组临床有效率为80.43%，显著低于治疗组的95.65%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组临床症状评分显著降低（P<0.05），GQOLI-74量表评分显著升高（P<0.05），同时治疗组治疗后临床症状和GQOLI-74量表评分明显优于对照组（P<0.05）。治疗后，两组血清IL-1β、单核细胞趋化蛋白-1（MCP-1）、肿瘤坏死因子-α（TNF-α）水平均显著降低（P<0.05），IL-2、干扰素-γ（IFN-γ）水平均显著升高（P<0.05），同时治疗后治疗组上述血清炎症指标明显优于对照组（P<0.05）。治疗后，对照组霉菌转阴率为52.17%，明显低于治疗组的86.96%，两组比较差异具有统计学意义（P<0.05）。结论 红核妇洁洗液联合克霉唑阴道片治疗霉菌性阴道炎可有效改善患者临床症状，利于炎症消退和阴道内环境的改善。

Objective To explore the clinical efficacy of Honghe Fujie Lotion combined with Clotrimazole Vaginal Tablets in treatment of colpitis mycotica. Methods Patients (92 cases) with colpitis mycotica in Henan Province Hospital from December 2015 to December 2016 were randomly divided into control (46 cases) and treatment (46 cases) groups. Patients in the control group were vagina deeply administered with Clotrimazole Vaginal Tablets, 1 tablet/d. Patients in the treatment group were vaginal rinsing and vulvar scrubbing administered with Honghe Fujie Lotion on the basis of the control group, diluted with clear water in proportion of 1:10, twice daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacy was evaluated, and the clinical symptom, GQOLI-74 scale scores, the serum inflammatory markers and mycete detection rate in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.43%, which was significantly lower than 95.65% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the clinical symptom scores in two groups were significantly decreased (P<0.05), but the GQOLI-74 scores were significantly increased (P<0.05), and these scores in the treatment group after treatment were significantly better than those in the control group (P<0.05). After treatment, the serum IL-1β, MCP-1 and TNF-α levels in two groups were significantly decreased (P<0.05), but the IL-2 and IFN-γ levels were significantly increased (P<0.05), and the serum inflammatory markers in the treatment group after treatment were significantly better than those in the control group (P<0.05). After treatment, the mycete detection rate in the control group was 52.17%, which was significantly lower than 86.96% in the treatment group, with significant difference between two groups (P<0.05). Conclusion Honghe Fujie Lotion combined with Clotrimazole Vaginal Tablets in treatment of colpitis mycotica can effectively improve the clinical symptoms, and which is conducive to inflammation resolution and improvement of the vagina microecosystem.