目的 研究养胃舒胶囊联合奥美拉唑肠溶胶囊治疗慢性胃炎的临床疗效。方法 选取2015年6月-2017年6月宁夏医科大学总医院收治的慢性胃炎患者120例为研究对象，将所有患者随机分为对照组和治疗组，每组各60例。对照组患者口服奥美拉唑肠溶胶囊，1粒/次，1次/d。治疗组在对照组的基础上口服养胃舒胶囊，3粒/次，2次/d。两组患者均连续治疗8周。观察两组的临床疗效，比较两组的血清炎症因子、氧化应激因子水平。结果 治疗后，对照组和治疗组的总有效率分别为85.00%、95.00%，两组比较差异有统计学意义（P<0.05）。两组血清白细胞介素-8（IL-8）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组血清炎症因子水平明显高于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者超氧化物歧化酶（SOD）、一氧化氮（NO）水平显著升高，丙二醛（MDA）水平显著下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组血清氧化应激因子水平明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 养胃舒胶囊联合奥美拉唑肠溶胶囊治疗慢性胃炎具有较好的临床疗效，可调节炎性因子和氧化应激因子水平，安全性较好，具有一定临床推广应用价值。

Objective To study the clinical effect of Yangweishu Capsules combined with Omeprazole Enteric-coated Capsules in treatment of chronic gastritis. Methods Patients (120 cases) with chronic gastritis in General Hospital of Ningxia Medical University from June 2015 to June 2017 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Omeprazole Enteric-coated Capsules, 1 grain/time, once daily. Patients in the treatment group were po administered with Yangweishu Capsules on the basis of the control group, 3 grains/time, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and the serum levels of inflammatory factors and oxidative stress factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 85.00% and 95.00%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of IL-8, IL-6, and TNF-α in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of SOD and NO in two groups were significantly increased, but the levels of MDA in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Yangweishu Capsules combined with Omeprazole Enteric-coated Capsules has clinical curative effect in treatment of chronic gastritis, can regulate the levels of inflammatory factor and oxidative stress factor, with good safety, which has a certain clinical application value.